Lin Yi-wei, Hu Zheng-hui, Wang Xiao, Mao Qi-qi, Qin Jie, Zheng Xiang-yi, Xie Li-ping
Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Qingchun Road 79, Hangzhou 310003, Zhejiang Province, China.
World J Surg Oncol. 2014 Feb 14;12:38. doi: 10.1186/1477-7819-12-38.
Tea is supposed to have chemopreventive effect against various cancers. However, the protective role of tea in prostate cancer is still controversial. The aim of this study is to elucidate the association between tea consumption and prostate cancer risk by meta-analysis.
A total of 21 published articles were retrieved via both computerized searches and review of references. Estimates of OR/RR for highest versus non/lowest tea consumption levels were pooled on the basis of random effect model or fixed effect model as appropriate. Stratified analyses on tea type, population and study design were also conducted.
No statistical significance was detected between tea consumption and prostate cancer risk in meta-analysis of all included studies (odds ratio (OR) = 0.86, 95% CI (0.69-1.04)). Furthermore, stratified analyses on population (Asian, OR = 0.81, 95% CI (0.55-1.08); non-Asian, OR = 0.89, 95% CI (0.72-1.07)) and tea type (green tea, OR = 0.79, 95% CI (0.43-1.14); black tea, OR = 0.88, 95% CI (0.73-1.02)) also yielded non-significant association. Only the case-control study subgroup demonstrated a borderline protective effect for tea consumption against prostate cancer (OR = 0.77, 95% CI (0.55-0.98)).
Our analyses did not support the conclusion that tea consumption could reduce prostate cancer risk. Further epidemiology studies are needed.
茶被认为对多种癌症具有化学预防作用。然而，茶在前列腺癌中的保护作用仍存在争议。本研究的目的是通过荟萃分析阐明饮茶与前列腺癌风险之间的关联。
通过计算机检索和参考文献回顾共检索到21篇已发表的文章。根据最高与非/最低饮茶水平的比值比（OR）/风险比（RR）估计值，酌情采用随机效应模型或固定效应模型进行合并。还对茶的类型、人群和研究设计进行了分层分析。
在所有纳入研究的荟萃分析中，未检测到饮茶与前列腺癌风险之间的统计学显著差异（优势比（OR）=0.86，95%置信区间（CI）（0.69 - 1.04））。此外，对人群（亚洲人，OR = 0.81，95% CI（0.55 - 1.08）；非亚洲人，OR = 0.89，95% CI（0.72 - 1.07））和茶的类型（绿茶，OR = 0.79，95% CI（0.43 - 1.14）；红茶，OR = 0.88，95% CI（0.73 - 1.02））的分层分析也未显示出显著关联。只有病例对照研究亚组显示饮茶对前列腺癌有临界保护作用（OR = 0.77，95% CI（0.55 - 0.98））。
我们的分析不支持饮茶可降低前列腺癌风险这一结论。需要进一步的流行病学研究。
