Lelic Melisa, Bogdanovic Gordana, Ramic Suada, Brkicevic Elvira
University of Tuzla, Medical Faculty, Department of histology and embryology, Tuzla, Bosnia and Herzegovina.
University Clinical Center Tuzla, Clinic for Gynecology and obstetrics, Tuzla, Bosnia and Herzegovina.
Med Arch. 2014 Jun;68(3):184-7. doi: 10.5455/medarh.2014.68.184-187. Epub 2014 May 31.
Sideropenic anemia is a common pregnancy disorder. Depending on severity, maternal anemia can significantly influence morphometric characteristic of placental tissue, pregnancy course and outcome.
to estimate if maternal anemia a) results with significant placental changes; b) influence on newborn weight, length and vitality.
Research included 100 women and their newborns, 50 anemic, and 50 women in the control group. Sixty placentas were collected, placental mass and volume was determined, and blood vessels of terminal villi were stereologically analyzed. Newborns mass and body length, and Apgar scores within 1 and 5 minutes after delivery were recorded.
Placentas of anemic pregnant women showed significant increase of terminal villi blood vessels (224,18 vs. 197,00 cm(3); p<0,0001), but total placental mass and volume did not differ significantly. Anemic mothers' newborns were significantly shorter (51,76 vs. 55,54 cm; p<0,0001), smaller body mass (3048,00 vs. 3615,60 g; p<0,0001) and delivered one week early (38,2 vs. 39,2 GW; p<0,0001), but not significantly poorer vitality (p>0,05) comparing with the control group.
Sideropenic anemia increase placental maturity, that could be a possible cause of earlier spontaneous delivery among anemic women. The anemic mothers' newborns are shorter and lower body mass, but not poorer vitality index.
缺铁性贫血是一种常见的妊娠疾病。根据严重程度，母体贫血会显著影响胎盘组织的形态特征、妊娠过程及结局。
评估母体贫血是否a）导致胎盘发生显著变化；b）影响新生儿体重、身长及活力。
研究纳入100名女性及其新生儿，其中50名贫血女性，50名作为对照组。收集60份胎盘，测定胎盘重量和体积，并对终末绒毛血管进行体视学分析。记录新生儿体重、身长以及出生后1分钟和5分钟的阿氏评分。
贫血孕妇的胎盘终末绒毛血管显著增多（224.18 vs. 197.00 cm³；p<0.0001），但胎盘总重量和体积无显著差异。贫血母亲的新生儿明显更矮（51.76 vs. 55.54 cm；p<0.0001）、体重更小（3048.00 vs. 3615.60 g；p<0.0001）且提前一周分娩（38.2 vs. 39.2孕周；p<0.0001），但与对照组相比，活力并无显著降低（p>0.05）。
缺铁性贫血会增加胎盘成熟度，这可能是贫血女性更早发生自然分娩的一个潜在原因。贫血母亲的新生儿身材更矮、体重更低，但活力指数并不更低。
