具有抗HIV活性的凝集素：综述
Lectins with anti-HIV activity: a review.
作者信息
Akkouh Ouafae, Ng Tzi Bun, Singh Senjam Sunil, Yin Cuiming, Dan Xiuli, Chan Yau Sang, Pan Wenliang, Cheung Randy Chi Fai
机构信息
Department of Biology and Medical Laboratory Research, Faculty of Technology, University of Applied Sciences Leiden, Zernikdreef 11, 2333 CK Leiden, The Netherlands.
School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
出版信息
Molecules. 2015 Jan 6;20(1):648-68. doi: 10.3390/molecules20010648.
Lectins including flowering plant lectins, algal lectins, cyanobacterial lectins, actinomycete lectin, worm lectins, and the nonpeptidic lectin mimics pradimicins and benanomicins, exhibit anti-HIV activity. The anti-HIV plant lectins include Artocarpus heterophyllus (jacalin) lectin, concanavalin A, Galanthus nivalis (snowdrop) agglutinin-related lectins, Musa acuminata (banana) lectin, Myrianthus holstii lectin, Narcissus pseudonarcissus lectin, and Urtica diocia agglutinin. The anti-HIV algal lectins comprise Boodlea coacta lectin, Griffithsin, Oscillatoria agardhii agglutinin. The anti-HIV cyanobacterial lectins are cyanovirin-N, scytovirin, Microcystis viridis lectin, and microvirin. Actinohivin is an anti-HIV actinomycete lectin. The anti-HIV worm lectins include Chaetopterus variopedatus polychaete marine worm lectin, Serpula vermicularis sea worm lectin, and C-type lectin Mermaid from nematode (Laxus oneistus). The anti-HIV nonpeptidic lectin mimics comprise pradimicins and benanomicins. Their anti-HIV mechanisms are discussed.
凝集素包括开花植物凝集素、藻类凝集素、蓝细菌凝集素、放线菌凝集素、蠕虫凝集素以及非肽类凝集素模拟物普拉地米星和贝那米星，都具有抗HIV活性。抗HIV植物凝集素包括面包果（jacalin）凝集素、伴刀豆球蛋白A、雪花莲（雪滴花）凝集素相关凝集素、香蕉凝集素、霍氏串果藤凝集素、水仙凝集素和荨麻凝集素。抗HIV藻类凝集素包括紧密布氏藻凝集素、格里菲斯病毒蛋白、阿氏颤藻凝集素。抗HIV蓝细菌凝集素是蓝藻素-N、鞘丝藻素、微囊藻凝集素和微小病毒素。放线菌素是一种抗HIV放线菌凝集素。抗HIV蠕虫凝集素包括多毛纲海蠕虫变异帚毛虫凝集素、盘管虫海蠕虫凝集素以及来自线虫（拉克斯单肠虫）的C型凝集素美人鱼凝集素。抗HIV非肽类凝集素模拟物包括普拉地米星和贝那米星。文中讨论了它们的抗HIV机制。
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