Zhang Ming-Zhi, Harris Raymond C
Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
Curr Opin Nephrol Hypertens. 2015 Mar;24(2):117-22. doi: 10.1097/MNH.0000000000000104.
This review will highlight recent findings concerning the regulation and signalling of the intrarenal dopaminergic system and the emerging evidence for its importance in blood pressure regulation.
There is an increasing evidence that the intrarenal dopaminergic system plays an important role in the regulation of blood pressure, and defects in dopamine signalling appear to be involved in the development of hypertension. Recent experimental models have definitively demonstrated that abnormalities in intrarenal dopamine production or receptor signalling can predispose to salt-sensitive hypertension and a dysregulated renin-angiotensin system. There are also new results indicating the importance of dopamine receptor mediated regulation of salt and water homeostasis along the nephron, and new studies indicating the role that the intrarenal dopaminergic system plays to mitigate the production of reactive oxygen species and progression of chronic renal disease.
New studies underscore the importance of the intrarenal dopaminergic system in the regulation of renal function and indicate how alterations in dopamine production or signalling may underlie the development of hypertension and kidney injury.
本综述将重点介绍有关肾内多巴胺能系统调节和信号传导的最新研究结果，以及其在血压调节中重要性的新证据。
越来越多的证据表明，肾内多巴胺能系统在血压调节中起重要作用，多巴胺信号传导缺陷似乎与高血压的发生有关。最近的实验模型已明确证明，肾内多巴胺生成或受体信号传导异常可导致盐敏感性高血压和肾素 - 血管紧张素系统失调。也有新结果表明多巴胺受体介导的沿肾单位调节盐和水平衡的重要性，以及新研究表明肾内多巴胺能系统在减轻活性氧生成和慢性肾病进展方面的作用。
新研究强调了肾内多巴胺能系统在肾功能调节中的重要性，并指出多巴胺生成或信号传导的改变可能是高血压和肾损伤发生的基础。
