Bouloc Anne, Vergnanini Andre Luiz, Issa Maria Claudia
Vichy Laboratoires, Asnières, France.
J Cosmet Dermatol. 2015 Mar;14(1):40-6. doi: 10.1111/jocd.12131. Epub 2015 Jan 21.
Topical tretinoin is considered the gold standard to treat photoaged skin, but it is associated with side effects and only available upon prescription.
To compare the efficacy, tolerance, and perception of a fixed proprietary combination (Retinol 0.2%/LR2412 2%) vs. tretinoin 0.025% cream in women with photoaged skin.
MATERIAL/METHODS: In this randomized, parallel, double-blind, controlled clinical study, women applied to the entire face for 3 months in the morning a SPF 50 sunscreen and in the evening either the association of Retinol 0.2%/LR2412 2% or tretinoin 0.025%. Clinical and instrumental parameters were assessed at days 0, 28, 56, and 84. Subject perception of the efficacy, tolerance and cosmeticity of the tested products were assessed at days 28, 56, and 84.
A total of 120 women (60 to Retinol 0.2%/LR2412 2% cream and 60 to tretinoin 0.025% cream) were included in the study. Both products improved considerably wrinkles, mottled pigmentation, pores, and global photodamage. No statistically significant differences were noted between Retinol 0.2%/LR2412 2% cream and tretinoin 0.025% cream. Adverse effects were mostly graded mild. Overall, Retinol 0.2%/LR2412 2% cream was better tolerated than tretinoin 0.025% cream. At all visits, subject perception of the association of Retinol 0.2%/LR2412 2% was either comparable to or better than tretinoin 0.025% cream.
The treatment outcome of Retinol 0.2%/LR2412 2% cream does not differ from the one of tretinoin 0.025% cream. Clinical results were not statistically different. Furthermore, Retinol 0.2%/LR2412 2% cream is better tolerated and better perceived by women used to rejuvenation procedures.
外用维甲酸被认为是治疗光老化皮肤的金标准，但它存在副作用且只能凭处方获得。
比较含0.2%视黄醇/2%LR2412的固定专利组合产品与0.025%维甲酸乳膏对光老化女性皮肤的疗效、耐受性及使用感受。
材料/方法：在这项随机、平行、双盲、对照临床研究中，女性受试者每天早晨全脸涂抹防晒指数为50的防晒霜，晚上分别涂抹含0.2%视黄醇/2%LR2412的组合产品或0.025%维甲酸乳膏，持续3个月。在第0、28、56和84天评估临床和仪器参数。在第28、56和84天评估受试者对受试产品疗效、耐受性和美观度的感受。
共有120名女性（60名使用含0.2%视黄醇/2%LR2412的乳膏，60名使用0.025%维甲酸乳膏）纳入研究。两种产品均显著改善了皱纹、色素沉着、毛孔及整体光损伤。含0.2%视黄醇/2%LR2412的乳膏与0.025%维甲酸乳膏之间未观察到统计学上的显著差异。不良反应大多为轻度。总体而言，含0.2%视黄醇/2%LR2412的乳膏耐受性优于0.025%维甲酸乳膏。在所有访视中，受试者对含0.2%视黄醇/2%LR2412组合产品的评价与0.025%维甲酸乳膏相当或更好。
含0.2%视黄醇/2%LR2412的乳膏的治疗效果与0.025%维甲酸乳膏无异。临床结果无统计学差异。此外，含0.2%视黄醇/2%LR2412的乳膏耐受性更好，更受习惯使用嫩肤程序的女性青睐。
