鲸类动物的进化：来自小须鲸基因组序列的见解
Cetaceans evolution: insights from the genome sequences of common minke whales.
作者信息
Park Jung Youn, An Yong-Rock, Kanda Naohisa, An Chul-Min, An Hye Suck, Kang Jung-Ha, Kim Eun Mi, An Du-Hae, Jung Hojin, Joung Myunghee, Park Myung Hum, Yoon Sook Hee, Lee Bo-Young, Lee Taeheon, Kim Kyu-Won, Park Won Cheoul, Shin Dong Hyun, Lee Young Sub, Kim Jaemin, Kwak Woori, Kim Hyeon Jeong, Kwon Young-Jun, Moon Sunjin, Kim Yuseob, Burt David W, Cho Seoae, Kim Heebal
机构信息
Biotechnology Research Division, National Fisheries Research & Development Institute, Gijang gun, Busan, 619-705, Republic of Korea.
Cetacean Research Institute, National Fisheries Research & Development Institute, Nam-gu, Ulsan, 680-050, Republic of Korea.
出版信息
BMC Genomics. 2015 Jan 22;16(1):13. doi: 10.1186/s12864-015-1213-1.
BACKGROUND
Whales have captivated the human imagination for millennia. These incredible cetaceans are the only mammals that have adapted to life in the open oceans and have been a source of human food, fuel and tools around the globe. The transition from land to water has led to various aquatic specializations related to hairless skin and ability to regulate their body temperature in cold water.
RESULTS
We present four common minke whale (Balaenoptera acutorostrata) genomes with depth of ×13 ~ ×17 coverage and perform resequencing technology without a reference sequence. Our results indicated the time to the most recent common ancestors of common minke whales to be about 2.3574 (95% HPD, 1.1521 - 3.9212) million years ago. Further, we found that genes associated with epilation and tooth-development showed signatures of positive selection, supporting the morphological uniqueness of whales.
CONCLUSIONS
This whole-genome sequencing offers a chance to better understand the evolutionary journey of one of the largest mammals on earth.
背景
数千年来，鲸鱼一直吸引着人类的想象力。这些令人惊叹的鲸目动物是唯一适应在开阔海洋生活的哺乳动物，在全球范围内一直是人类食物、燃料和工具的来源。从陆地到水中的转变导致了各种与无毛皮肤以及在冷水中调节体温能力相关的水生特化。
结果
我们展示了四个普通小须鲸（Balaenoptera acutorostrata）基因组，覆盖深度为×13至×17，并在没有参考序列的情况下进行了重测序技术。我们的结果表明，普通小须鲸最近共同祖先的时间约为235.74万（95% HPD，115.21 - 392.12）年前。此外，我们发现与脱毛和牙齿发育相关的基因显示出正选择的特征，支持了鲸鱼的形态独特性。
结论
这种全基因组测序为更好地了解地球上最大的哺乳动物之一的进化历程提供了一个机会。
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