Weaver Connie M
Department of Nutrition Science, Purdue University, Wet Lafayette, IN, 47907-2059, USA,
Curr Osteoporos Rep. 2015 Apr;13(2):125-30. doi: 10.1007/s11914-015-0257-0.
Interactions between the environment, the gut microbiome, and host characteristics that influence bone health are beginning to be explored. This is the first area where functional benefits from diet-induced changes in the gut microbiome have been reported for healthy people. Several prebiotics that reach the lower intestine have resulted in an altered gut microbiome that is thought to enhance fermentation of the fibers to produce short-chain fatty acids. These changes are positively correlated with increases in fractional calcium absorption in adolescents and with increases in measures of bone density and strength in animal models. New methodologies are available to explore mechanisms and to refine intervention strategies.
环境、肠道微生物群和影响骨骼健康的宿主特征之间的相互作用正开始得到探索。这是首次有报告称，饮食引起的肠道微生物群变化对健康人群具有功能益处的领域。几种到达下肠道的益生元已导致肠道微生物群发生改变，据认为这种改变会增强纤维发酵以产生短链脂肪酸。这些变化与青少年钙吸收分数的增加以及动物模型中骨密度和强度测量值的增加呈正相关。现在有新的方法可用于探索机制和完善干预策略。
