Key Laboratory of Environmental Medicine Engineering in Ministry of Education, Medical School of Southeast University, Nanjing 210009, China.
Institute of Health and Environmental Medicine, Key Laboratory of Risk Assessment and Control Technology for Environmental & Food Safety, Tianjin 300050, China.
Sci Total Environ. 2015 Apr 15;512-513:251-260. doi: 10.1016/j.scitotenv.2015.01.058. Epub 2015 Jan 24.
The toxic effects of coal combustion related fine particulate matter (PM2.5), collected from Datong, Shanxi province, China, on nematode Caenorhabditis elegans were investigated. Exposure to PM2.5 resulted in deficits in development, reproduction, locomotion behavior, and lifespan, and induction of intestinal autofluorescence or reactive oxygen species (ROS) production. Prolonged exposure to PM2.5 led to more severe toxicity on nematodes than acute exposure. In addition, exposure to PM2.5 induced altered expression patterns of genes required for the control of oxidative stress. Reduction in mean defecation cycle length and developmental deficits in AVL and DVB neurons, which are involved in the control of defecation behavior, were also triggered by PM2.5 exposure. Thus, oxidative stress and abnormal defecation behavior may contribute greatly to the toxicity of coal combustion related PM2.5 in nematodes. The results also imply that the long-term adverse effects of coal combustion related PM2.5 on environmental organisms should be carefully considered.
研究了来自中国山西省大同市的燃煤相关细颗粒物（PM2.5）对秀丽隐杆线虫的毒性作用。暴露于 PM2.5 会导致发育、繁殖、运动行为和寿命缺陷，并诱导肠道自发荧光或活性氧（ROS）产生。与急性暴露相比，长时间暴露于 PM2.5 会对线虫产生更严重的毒性。此外，暴露于 PM2.5 会诱导控制氧化应激所需基因的表达模式发生改变。PM2.5 暴露还会导致与控制排粪行为相关的 AVL 和 DVB 神经元的平均排粪周期长度缩短和发育缺陷。因此，氧化应激和异常排粪行为可能是导致线虫中燃煤相关 PM2.5 毒性的主要原因。研究结果还表明，应仔细考虑燃煤相关 PM2.5 对环境生物的长期不良影响。
