肠道黏膜耐受性以及肠道微生物群对黏膜耐受性的影响。
Intestinal mucosal tolerance and impact of gut microbiota to mucosal tolerance.
作者信息
Chistiakov Dimitry A, Bobryshev Yuri V, Kozarov Emil, Sobenin Igor A, Orekhov Alexander N
机构信息
Department of Medical Nanobiotechnology, Pirogov Russian State Medical University , Moscow, Russia ; The Mount Sinai Community Clinical Oncology Program, Mount Sinai Comprehensive Cancer Center, Mount Sinai Medical Center , Miami Beach, FL, USA ; Research Center for Children's Health , Moscow, Russia.
Institute of General Pathology and Pathophysiology, Russian Academy of Sciences , Moscow, Russia ; Faculty of Medicine, School of Medical Sciences, University of New South Wales , Sydney, NSW, Australia ; School of Medicine, University of Western Sydney , Campbelltown, NSW, Australia.
出版信息
Front Microbiol. 2015 Jan 13;5:781. doi: 10.3389/fmicb.2014.00781. eCollection 2014.
The mucosal barriers are very sensitive to pathogenic infection, thereby assuming the capacity of the mucosal immune system to induce protective immunity to harmful antigens and tolerance against harmless substances. This review provides current information about mechanisms of induction of mucosal tolerance and about impact of gut microbiota to mucosal tolerance.
黏膜屏障对病原体感染非常敏感，因此黏膜免疫系统具有诱导针对有害抗原的保护性免疫以及对无害物质产生耐受性的能力。本综述提供了关于黏膜耐受性诱导机制以及肠道微生物群对黏膜耐受性影响的当前信息。
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