Hembury Mathew, Chiappini Ciro, Bertazzo Sergio, Kalber Tammy L, Drisko Glenna L, Ogunlade Olumide, Walker-Samuel Simon, Krishna Katla Sai, Jumeaux Coline, Beard Paul, Kumar Challa S S R, Porter Alexandra E, Lythgoe Mark F, Boissière Cédric, Sanchez Clément, Stevens Molly M
Department of Materials, Institute of Biomedical Engineering, and Department of Bioengineering, Imperial College London, London SW7 2AZ, United Kingdom;
Department of Materials, Institute of Biomedical Engineering, and.
Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):1959-64. doi: 10.1073/pnas.1419622112. Epub 2015 Feb 4.
Gold quantum dots exhibit distinctive optical and magnetic behaviors compared with larger gold nanoparticles. However, their unfavorable interaction with living systems and lack of stability in aqueous solvents has so far prevented their adoption in biology and medicine. Here, a simple synthetic pathway integrates gold quantum dots within a mesoporous silica shell, alongside larger gold nanoparticles within the shell's central cavity. This "quantum rattle" structure is stable in aqueous solutions, does not elicit cell toxicity, preserves the attractive near-infrared photonics and paramagnetism of gold quantum dots, and enhances the drug-carrier performance of the silica shell. In vivo, the quantum rattles reduced tumor burden in a single course of photothermal therapy while coupling three complementary imaging modalities: near-infrared fluorescence, photoacoustic, and magnetic resonance imaging. The incorporation of gold within the quantum rattles significantly enhanced the drug-carrier performance of the silica shell. This innovative material design based on the mutually beneficial interaction of gold and silica introduces the use of gold quantum dots for imaging and therapeutic applications.
与较大的金纳米颗粒相比，金量子点表现出独特的光学和磁学行为。然而，它们与生物系统的不良相互作用以及在水性溶剂中缺乏稳定性，迄今为止阻碍了它们在生物学和医学中的应用。在此，一种简单的合成途径将金量子点整合到介孔二氧化硅壳内，同时在壳的中心腔内含有较大的金纳米颗粒。这种“量子摇铃”结构在水溶液中稳定，不会引发细胞毒性，保留了金量子点吸引人的近红外光子学和顺磁性，并增强了二氧化硅壳的药物载体性能。在体内，量子摇铃在单一疗程的光热疗法中减轻了肿瘤负担，同时结合了三种互补的成像方式：近红外荧光、光声和磁共振成像。量子摇铃中金的掺入显著增强了二氧化硅壳的药物载体性能。这种基于金和二氧化硅互利相互作用的创新材料设计引入了金量子点用于成像和治疗应用。
