Frake Rebecca A, Ricketts Thomas, Menzies Fiona M, Rubinsztein David C
J Clin Invest. 2015 Jan;125(1):65-74. doi: 10.1172/JCI73944. Epub 2015 Jan 2.
Most neurodegenerative diseases that afflict humans are associated with the intracytoplasmic deposition of aggregate-prone proteins in neurons. Autophagy is a powerful process for removing such proteins. In this Review, we consider how certain neurodegenerative diseases may be associated with impaired autophagy and how this may affect pathology. We also discuss how autophagy induction may be a plausible therapeutic strategy for some conditions and review studies in various models that support this hypothesis. Finally, we briefly describe some of the signaling pathways that may be amenable to therapeutic targeting for these goals.
大多数困扰人类的神经退行性疾病都与神经元中易于聚集的蛋白质在细胞质内沉积有关。自噬是清除此类蛋白质的有效过程。在本综述中，我们探讨了某些神经退行性疾病如何可能与自噬受损相关，以及这如何影响病理过程。我们还讨论了自噬诱导为何可能是某些病症的合理治疗策略，并回顾了各种模型中支持这一假设的研究。最后，我们简要描述了一些可能适用于针对这些目标进行治疗靶向的信号通路。
