荷兰野生大鼠种群中首次发现汉城汉坦病毒的证据。
First evidence of Seoul hantavirus in the wild rat population in the Netherlands.
作者信息
Verner-Carlsson Jenny, Lõhmus Mare, Sundström Karin, Strand Tanja M, Verkerk Monique, Reusken Chantal, Yoshimatsu Kumiko, Arikawa Jiro, van de Goot Frank, Lundkvist Åke
机构信息
Department of Medical Biochemistry and Microbiology, Zoonosis Science Centre, Uppsala University, Uppsala, Sweden.
Public Health Agency of Sweden, Stockholm, Sweden.
出版信息
Infect Ecol Epidemiol. 2015 Feb 6;5:27215. doi: 10.3402/iee.v5.27215. eCollection 2015.
We report the first detection of Seoul hantavirus (SEOV)-specific antibodies in the wild brown rat population in the Netherlands. SEOV-reactive antibodies were found in three rats out of 16 in a repeated series of tests including immunofluorescence assay, immunoblot, and enzyme-linked immunosorbent assay. Focus reduction neutralization test confirmed the presence of SEOV-specific antibodies, and reverse-transcription polymerase chain reaction (RT-PCR) confirmed the presence of hantaviral RNA. This discovery follows the recent findings of SEOV infections in wild and pet brown rats and humans in England, Wales, France, Belgium, and Sweden, indicating an even higher importance of this hantavirus for public health in large areas of Europe.
我们报告了在荷兰野生褐家鼠种群中首次检测到汉城汉坦病毒（SEOV）特异性抗体。在包括免疫荧光试验、免疫印迹和酶联免疫吸附测定在内的一系列重复检测中，16只大鼠中有3只检测到SEOV反应性抗体。空斑减少中和试验证实了SEOV特异性抗体的存在，逆转录聚合酶链反应（RT-PCR）证实了汉坦病毒RNA的存在。这一发现是继最近在英国、威尔士、法国、比利时和瑞典的野生和宠物褐家鼠以及人类中发现SEOV感染之后得出的，表明这种汉坦病毒对欧洲大片地区的公共卫生具有更高的重要性。
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