Sardesai Vidyadhar R, Agarwal Trupti D, Sakhalkar Sarita P
Department of Dermatology, STD and Leprosy, Bharati Vidyapeeth Medical College, Pune, India.
Indian J Dermatol. 2015 Jan-Feb;60(1):105. doi: 10.4103/0019-5154.147870.
Extramammary Paget's disease is a marginated plaque resembling Paget's disease but occurring in anogenital area, axilla or most commonly on the vulva. A 62-year-old postmenopausal woman presented with extremely pruritic plaque on the perineal skin which progressed gradually over 3 years and did not respond to any topical/systemic steroids, antibiotics, and antifungals. Examination revealed 7 × 8 cm. hypertrophic, verrucous plaque with erosions, and crusts at places. There was no evidence of visceral malignancy. Biopsy showed Paget's cells which were positive for Periodic Acid Schiff and alcian blue stain. Surgical excision was done considering the premalignant potential.
乳腺外佩吉特病是一种边界清晰的斑块，类似于佩吉特病，但发生在肛门生殖器区域、腋窝，最常见于外阴。一名62岁的绝经后女性，会阴皮肤出现极度瘙痒的斑块，3年来逐渐进展，对任何局部/全身类固醇、抗生素和抗真菌药均无反应。检查发现有一个7×8厘米的肥厚性、疣状斑块，有糜烂和结痂处。没有内脏恶性肿瘤的证据。活检显示佩吉特细胞，过碘酸希夫染色和阿尔辛蓝染色呈阳性。考虑到其恶变潜能，进行了手术切除。
