Tanabe Y, Urata H, Kiyonaga A, Ikeda M, Tanaka H, Shindo M, Arakawa K
Department of Internal Medicine, School of Medicine, Fukuoka University.
Clin Exp Hypertens A. 1989;11(1):149-65. doi: 10.3109/10641968909035297.
Thirty-one Japanese with essential hypertension were divided into training (n = 21) and non-training (n = 10) groups. Physical training of 10 weeks was instituted after 4 or more weeks of observation, and changes in blood pressure and serum concentrations of taurine and other amino acids were investigated. The workload in physical training was predetermined by the submaximal multistage graded exercise test on a bicycle ergometer, and the blood lactate threshold which reflects approximately 40-60% of maximal oxygen uptake was chosen. The hypertensive patients underwent bicycle ergometer training for 60 minutes, three times a week for 10 weeks. Blood pressures were significantly decreased by 14.8/6.6 mmHg in systole/diastole in the training group, but not in the non-training group. Serum concentrations of taurine and cystine were increased significantly by 26% and 287%, in the training group. Increase in serum asparagine (11%), histidine (6%) and lysine (7%) concentrations was also significant, only in the training group. Plasma norepinephrine level and whole blood and plasma volumes were significantly reduced. The change in serum taurine level was significantly negatively correlated with the change in plasma norepinephrine. In addition there was a significant positive correlation between the change in plasma norepinephrine and the change in diastolic blood pressure in the training group. Based on these results, the increase in serum taurine which is known for its antihypertensive activity could contribute, at least in part through the reduction in plasma norepinephrine level, to the antihypertensive effect of exercise.
31名日本原发性高血压患者被分为训练组（n = 21）和非训练组（n = 10）。在观察4周或更长时间后进行为期10周的体育训练，并研究血压以及牛磺酸和其他氨基酸血清浓度的变化。体育训练的工作量通过自行车测力计上的次极量多级运动试验预先确定，并选择反映大约40 - 60%最大摄氧量的血乳酸阈值。高血压患者在自行车测力计上进行60分钟训练，每周3次，共10周。训练组收缩压/舒张压显著降低14.8/6.6 mmHg，而非训练组未降低。训练组牛磺酸和胱氨酸血清浓度显著增加26%和287%。仅训练组血清天冬酰胺（11%）、组氨酸（6%）和赖氨酸（7%）浓度的增加也很显著。血浆去甲肾上腺素水平以及全血和血浆容量显著降低。血清牛磺酸水平的变化与血浆去甲肾上腺素变化显著负相关。此外，训练组血浆去甲肾上腺素变化与舒张压变化之间存在显著正相关。基于这些结果，已知具有降压活性的血清牛磺酸增加至少部分通过降低血浆去甲肾上腺素水平，对运动的降压作用有贡献。
