Li Wanwan, Rong Pengfei, Yang Kai, Huang Peng, Sun Kang, Chen Xiaoyuan
State Key Lab of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China; Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, USA; State Key Laboratory for Powder Metallurgy, Central South University, Changsha, Hunan 410083, China; Department of Radiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
Biomaterials. 2015 Mar;45:18-26. doi: 10.1016/j.biomaterials.2014.12.037. Epub 2015 Jan 13.
In this study we report semimetal nanomaterials of antimony (Sb) as highly efficient agent for photoacoustic imaging (PAI) and photothermal therapy (PTT). The Sb nanorod bundles have been synthesized through a facile route by mixing 1-octadecane (ODE) and oleyl amine (OAm) as the solvent. The aqueous dispersion of PEGylated Sb NPs, due to its broad and strong photoabsorption ranging from ultraviolet (UV) to near-infrared (NIR) wavelengths, is applicable as a photothermal agent driven by 808 nm laser with photothermal conversion efficiency up to 41%, noticeably higher than most of the PTT agents reported before. Our in vitro experiments also showed that cancer cell ablation effect of PEGylated Sb NPs was dependent on laser power. By intratumoral administration of PEGylated Sb NPs, 100% tumor ablation can be realized by using NIR laser irradiation with a lower power of 1 W/cm(2) for 5 min (or 0.5 W/cm(2) for 10 min) and no obvious toxic side effect is identified after photothermal treatment. Moreover, intense PA signal was also observed after intratumoral injection of PEGylated Sb NPs and NIR laser irradiation due to their strong NIR photoabsorption, suggesting PEGylated Sb NPs as a potential NIR PA agent. Based on the findings of this work, further development of using other semimetal nanocrystals as highly efficient NIR agents can be achieved for vivo tumor imaging and PTT.
在本研究中，我们报道了锑（Sb）半金属纳米材料作为用于光声成像（PAI）和光热疗法（PTT）的高效剂。通过将1-十八烷（ODE）和油胺（OAm）作为溶剂混合，采用简便的方法合成了Sb纳米棒束。聚乙二醇化Sb纳米颗粒的水分散体由于其在从紫外（UV）到近红外（NIR）波长范围内具有广泛而强烈的光吸收，可作为由808 nm激光驱动的光热剂，光热转换效率高达41%，明显高于之前报道的大多数PTT剂。我们的体外实验还表明，聚乙二醇化Sb纳米颗粒的癌细胞消融效果取决于激光功率。通过瘤内注射聚乙二醇化Sb纳米颗粒，使用1 W/cm²的较低功率近红外激光照射5分钟（或0.5 W/cm²照射10分钟）可实现100%的肿瘤消融，光热处理后未发现明显的毒副作用。此外，由于聚乙二醇化Sb纳米颗粒强烈的近红外光吸收，在瘤内注射聚乙二醇化Sb纳米颗粒并进行近红外激光照射后也观察到强烈的PA信号，表明聚乙二醇化Sb纳米颗粒是一种潜在的近红外PA剂。基于这项工作的发现，使用其他半金属纳米晶体作为高效近红外剂进行体内肿瘤成像和PTT的进一步开发是可以实现的。
