Leonard Carmen M, Viljoen Alvaro M
Department of Pharmaceutical Sciences, Faculty of Science, Tshwane University of Technology, Private Bag X680, Pretoria 0001, South Africa.
Department of Pharmaceutical Sciences, Faculty of Science, Tshwane University of Technology, Private Bag X680, Pretoria 0001, South Africa.
J Ethnopharmacol. 2015 May 13;165:260-85. doi: 10.1016/j.jep.2015.02.021. Epub 2015 Feb 17.
The genus Warburgia (Canellaceae) is represented by several medicinal trees found exclusively on the African continent. Traditionally, extracts and products produced from Warburgia species are regarded as important natural African antibiotics and have been used extensively as part of traditional healing practices for the treatment of fungal, bacterial and protozoal infections in both humans and animals. We here aim to collate and review the fragmented information on the ethnobotany, phytochemistry and biological activities of ethnomedicinally important Warburgia species and present recommendations for future research.
Peer-reviewed articles using "Warburgia" as search term ("all fields") were retrieved from Scopus, ScienceDirect, SciFinder and Google Scholar with no specific time frame set for the search. In addition, various books were consulted that contained botanical and ethnopharmacological information.
The ethnopharmacology, phytochemistry and biological activity of Warburgia are reviewed. Most of the biological activities are attributed to the drimane sesquiterpenoids, including polygodial, warburganal, muzigadial, mukaadial and ugandensial, flavonoids and miscellaneous compounds present in the various species. In addition to anti-infective properties, Warburgia extracts are also used to treat a wide range of ailments, including stomach aches, fever and headaches, which may also be a manifestation of infections. The need to record anecdotal evidence is emphasised and conservation efforts are highlighted to contribute to the protection and preservation of one of Africa's most coveted botanical resources.
瓦尔堡属（林仙科）由几种仅在非洲大陆发现的药用树木代表。传统上，瓦尔堡属植物的提取物和产品被视为重要的非洲天然抗生素，并已广泛用作传统治疗方法的一部分，用于治疗人类和动物的真菌、细菌和原生动物感染。我们的目的是整理和综述关于具有民族药用价值的瓦尔堡属植物的民族植物学、植物化学和生物活性的零散信息，并提出未来研究的建议。
从Scopus、ScienceDirect、SciFinder和谷歌学术中检索以“瓦尔堡属”为搜索词（“所有字段”）的同行评审文章，搜索未设定特定时间范围。此外，还查阅了各种包含植物学和民族药理学信息的书籍。
对瓦尔堡属植物的民族药理学、植物化学和生物活性进行了综述。大多数生物活性归因于三环倍半萜类化合物，包括多香姜醛、瓦尔堡醛、穆齐加醛、穆卡醛和乌干达醛、黄酮类化合物以及各物种中存在的其他化合物。除抗感染特性外，瓦尔堡属植物提取物还用于治疗多种疾病，包括胃痛、发烧和头痛，这些也可能是感染的表现。强调了记录轶事证据的必要性，并突出了保护努力，以促进对非洲最令人垂涎的植物资源之一的保护和保存。
