心律失常发生的离子机制。
Ionic mechanisms of arrhythmogenesis.
作者信息
Anumonwo Justus M, Pandit Sandeep V
机构信息
Department of Internal Medicine-Cardiology, Center for Arrhythmia Research, University of Michigan, Ann Arbor, MI; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI.
Department of Internal Medicine-Cardiology, Center for Arrhythmia Research, University of Michigan, Ann Arbor, MI.
出版信息
Trends Cardiovasc Med. 2015 Aug;25(6):487-96. doi: 10.1016/j.tcm.2015.01.005. Epub 2015 Jan 16.
The understanding of ionic mechanisms underlying cardiac rhythm disturbances (arrhythmias) is an issue of significance in the medical science community. Several advances in molecular, cellular, and optical techniques in the past few decades have substantially increased our knowledge of ionic mechanisms that are thought to underlie arrhythmias. The application of these techniques in the study of ion channel biophysics and regulatory properties has provided a wealth of information, with some important therapeutic implications for dealing with the disease. In this review, we briefly consider the cellular and tissue manifestations of a number of cardiac rhythm disturbances, while focusing on our current understanding of the ionic current mechanisms that have been implicated in such rhythm disturbances.
理解心脏节律紊乱（心律失常）背后的离子机制是医学界的一个重要问题。在过去几十年里，分子、细胞和光学技术的几项进展极大地增加了我们对被认为是心律失常基础的离子机制的认识。这些技术在离子通道生物物理学和调节特性研究中的应用提供了丰富的信息，对该疾病的治疗具有一些重要意义。在这篇综述中，我们简要考虑了一些心脏节律紊乱的细胞和组织表现，同时重点关注我们目前对与此类节律紊乱相关的离子电流机制的理解。
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