Tse Gary
School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong.
J Arrhythm. 2016 Apr;32(2):75-81. doi: 10.1016/j.joa.2015.11.003. Epub 2015 Dec 17.
Blood circulation is the result of the beating of the heart, which provides the mechanical force to pump oxygenated blood to, and deoxygenated blood away from, the peripheral tissues. This depends critically on the preceding electrical activation. Disruptions in the orderly pattern of this propagating cardiac excitation wave can lead to arrhythmias. Understanding of the mechanisms underlying their generation and maintenance requires knowledge of the ionic contributions to the cardiac action potential, which is discussed in the first part of this review. A brief outline of the different classification systems for arrhythmogenesis is then provided, followed by a detailed discussion for each mechanism in turn, highlighting recent advances in this area.
血液循环是心脏跳动的结果，心脏提供机械力将含氧血液泵送到外周组织，并将脱氧血液从外周组织泵出。这关键取决于先前的电激活。这种传播的心脏兴奋波的有序模式受到干扰会导致心律失常。要了解心律失常产生和维持的机制，需要了解离子对心脏动作电位的作用，这将在本综述的第一部分进行讨论。接着将简要概述心律失常发生的不同分类系统，然后依次对每种机制进行详细讨论，突出该领域的最新进展。
