a Department of Oriental Medicinal Biotechnology , College of Life Sciences, Kyung Hee University , Yongin , 446-701 , Republic of Korea.
b Graduate School of Biotechnology and Ginseng Bank, College of Life Sciences, Kyung Hee University , Yongin , 446-701 , Republic of Korea.
Artif Cells Nanomed Biotechnol. 2016 May;44(3):811-6. doi: 10.3109/21691401.2015.1008514. Epub 2015 Feb 23.
In the present study, we report a green methodology for the synthesis of silver and gold nanoparticles, using the root extract of the herbal medicinal plant Korean red ginseng. The silver and gold nanoparticles were synthesized within 1 h and 10 min respectively. The nanoparticles generated were not aggregated, and remained stable for a long time, which suggests the nature of nanoparticles. The phytochemicals and ginsenosides present in the root extract assist in reducing and stabilizing the synthesized nanoparticles. The red ginseng root extract-generated silver nanoparticles exhibit antimicrobial activity against pathogenic microorganisms including Vibrio parahaemolyticus, Staphylococcus aureus, Bacillus cereus, and Candida albicans. In addition, the silver nanoparticles exhibit biofilm degrading activity against S. aureus and Pseudomonas aeruginosa. Thus, the present study opens up a new possibility of synthesizing silver and gold nanoparticles in a green and rapid manner using Korean red ginseng root extract, and explores their biomedical applications.
在本研究中，我们报告了一种使用草药植物高丽红参根提取物合成银和金纳米粒子的绿色方法。银和金纳米粒子分别在 1 小时和 10 分钟内合成。生成的纳米粒子没有聚集，并且长时间保持稳定，这表明了纳米粒子的性质。根提取物中存在的植物化学物质和人参皂苷有助于还原和稳定合成的纳米粒子。高丽红参根提取物生成的银纳米粒子对包括副溶血性弧菌、金黄色葡萄球菌、蜡状芽孢杆菌和白色念珠菌在内的致病微生物具有抗菌活性。此外，银纳米粒子对金黄色葡萄球菌和铜绿假单胞菌具有生物膜降解活性。因此，本研究为使用高丽红参根提取物以绿色和快速的方式合成银和金纳米粒子开辟了新的可能性，并探索了它们在生物医学中的应用。
