Poeppl Wolfgang, Lagler Heimo, Raderer Markus, Sperr Wolfgang R, Zielinski Christoph, Herkner Harald, Burgmann Heinz
Clinical Division of Infectious Diseases and Tropical Medicine, Department of Medicine I, Medical University of Vienna, 1090 Vienna, Austria.
Clinical Division of Oncology, Department of Medicine I, Medical University of Vienna, 1090 Vienna, Austria.
Vaccine. 2015 Mar 30;33(14):1682-7. doi: 10.1016/j.vaccine.2015.02.029. Epub 2015 Feb 24.
Patients with malignancies are at increased risk of serious influenza related complications with higher rates of hospitalization and mortality than healthy cohorts. Although annual vaccination against influenza infection is recommended, vaccination rates among cancer patients are apparently low. The reasons for the low compliance to influenza vaccine and the influenza vaccination rate among Austrian cancer patients have not been studied in detail yet.
From July 1, 2013 to October 31, 2013, 444 patients treated in the outpatient departments of the Clinical Division of Oncology and the Clinical Division of Haematology and Haemostaseology of the General Hospital Vienna participated in a survey on different aspects of influenza vaccination.
In total, only 80 out of 444 patients (18%) had received influenza vaccination in the previous year. The influenza vaccination rate was higher amongst patients with haematological malignancies (22%) compared to patients with solid tumours (13%). Higher age was significantly associated with a higher probability for being vaccinated. Collecting information about influenza vaccination primarily from media or the internet was not significantly associated with influenza vaccination status. Information through a medical consultation or a recommendation by the attending physician resulted in significant higher influenza vaccination coverage rates. Only 199 out of the 444 patients (44.8%) were informed by a physician about influenza vaccination and only 18 out of 337 patients (5.3%) with a diagnosis of a malignant disease were informed by their treating oncologist. The main reasons for influenza vaccination denial were concerns about interaction with the malignant disease and potential side-effects.
Information about influenza vaccination during a medical consultation and a clear recommendation by the attending physician are highly predictive for acceptance of influenza vaccination. Increased awareness among physicians, especially oncologists is of utmost importance to effectively improve IVR in patients with malignant disease.
恶性肿瘤患者发生严重流感相关并发症的风险增加，与健康人群相比，其住院率和死亡率更高。尽管建议每年接种流感疫苗，但癌症患者的接种率显然较低。奥地利癌症患者对流感疫苗依从性低及流感疫苗接种率低的原因尚未得到详细研究。
2013年7月1日至2013年10月31日，维也纳总医院肿瘤临床科和血液学与止血学临床科门诊治疗的444例患者参与了一项关于流感疫苗接种不同方面的调查。
在444例患者中，共有80例（18%）在前一年接种了流感疫苗。血液系统恶性肿瘤患者的流感疫苗接种率（22%）高于实体瘤患者（13%）。年龄越大，接种疫苗的可能性越高。主要从媒体或互联网获取流感疫苗接种信息与流感疫苗接种状况无显著关联。通过医疗咨询或主治医生的建议获得的信息导致流感疫苗接种覆盖率显著更高。444例患者中只有199例（44.8%）得到医生关于流感疫苗接种的告知，在337例诊断为恶性疾病的患者中，只有18例（5.3%）得到其主治肿瘤学家的告知。拒绝接种流感疫苗的主要原因是担心与恶性疾病相互作用及潜在副作用。
医疗咨询期间关于流感疫苗接种的信息以及主治医生的明确建议对接受流感疫苗接种具有高度预测性。提高医生尤其是肿瘤学家的意识对于有效提高恶性疾病患者的流感疫苗接种率至关重要。
