Duttagupta Dibyangana S, Jadhav Varsha M, Kadam Vilasrao J
University of Mumbai, Bharati Vidyapeeth's College of Pharmacy, Department of Quality Assurance, CBD Belapur, Sector-8, Navi-Mumbai-400614, India.
Curr Drug Deliv. 2015;12(4):369-81. doi: 10.2174/1567201812666150310151657.
Scientists have always been interested in the use of natural polymers for drug delivery. Chitosan, being a natural cationic polysaccharide has received a great deal of attention in the past few years. It is obtained by deacetylation of chitin and is regarded as the second most ubiquitous polymer subsequent to cellulose on earth. Unlike other natural polymers, the cationic charge possessed by chitosan is accountable for imparting interesting physical and chemical properties. Chitosan has been widely exploited for its mucoadhesive character, permeation enhancing properties and controlled release of drugs. Moreover it's non-toxic, biocompatible and biodegradable properties make it a good candidate for novel drug delivery system. This review provides an insight on various chitosan based formulations for drug delivery. Some of the current applications of chitosan in areas like ophthalmic, nasal, buccal, sublingual, gastro-retentive, pulmonary, transdermal, colon-specific and vaginal drug delivery have been discussed. In addition, active targeting of drugs to tumor cells using chitosan has been described. Lastly a brief section covering the safety aspects of chitosan has also been reviewed.
科学家们一直对天然聚合物在药物递送中的应用感兴趣。壳聚糖作为一种天然阳离子多糖，在过去几年中受到了广泛关注。它是通过甲壳素的脱乙酰化获得的，被认为是地球上仅次于纤维素的第二大普遍存在的聚合物。与其他天然聚合物不同，壳聚糖所具有的阳离子电荷赋予了它有趣的物理和化学性质。壳聚糖因其粘膜粘附特性、渗透增强特性和药物控释作用而被广泛应用。此外，它的无毒、生物相容性和可生物降解性使其成为新型药物递送系统的良好候选者。本综述深入探讨了各种基于壳聚糖的药物递送制剂。讨论了壳聚糖目前在眼科、鼻腔、口腔、舌下、胃滞留、肺部、透皮、结肠靶向和阴道药物递送等领域的一些应用。此外，还描述了使用壳聚糖将药物主动靶向肿瘤细胞的情况。最后，还简要回顾了壳聚糖的安全性方面。
