Marzec-Wróblewska Urszula, Kamiński Piotr, Łakota Paweł, Ludwikowski Grzegorz, Szymański Marek, Wasilow Karolina, Stuczyński Tomasz, Buciński Adam, Jerzak Leszek
Department of Biopharmacy, Faculty of Pharmacy, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, dr. A. Jurasz St. 2, 85-089, Bydgoszcz, Poland,
Arch Environ Contam Toxicol. 2015 Aug;69(2):191-201. doi: 10.1007/s00244-015-0143-x. Epub 2015 Mar 12.
The aim of the present study was to measure lanthanum (La), cerium (Ce), europium (Eu), and gadolinium (Gd) concentrations in human semen and correlate the results with sperm quality. The median semen content of La was 19.5 µg kg(-1) dry weight (dw) (range 2.27-269), of Ce was 41.9 µg kg(-1) dw (range 4.52 to 167), of Eu was 0.68 µg kg(-1) dw (range 0.06-1.95), of Gd was 3.19 µg kg(-1) dw (range 0.38-12.0), and of calcium (Ca) was 4063 mg kg(-1) dw (range 484-17,191). Concentrations of La, Ce, Eu, Gd, and Ca were significantly lower in nondrinkers' semen than in semen from drinkers. Significant differences were detected between La, Ce, Eu, Gd, and Ca concentrations in semen from nondrinkers and moderate drinkers. Concentrations of La, Ce, and Gd in semen of short-term smokers were significantly lower than those in extremely long-term smokers. Significant differences were also detected between La concentration in semen from a group of short-term smokers and that of a group of long-term smokers. Positive correlations were found between La, Ce, Eu, Gd, and Ca concentrations in semen. La, Ce, Gd, and Ca concentrations in semen were positively associated with progressive motility and percentage of normal spermatozoa. Positive correlations were found between Ca and sperm concentration. Concentrations of La, Ce, and Gd were negatively associated with sperm concentration, whilst Ca concentration was negatively associated with volume of ejaculate. At the examined level, La, Ce, Eu, and Gd did not affect sperm quality, whereas alcohol consumption and smoking might have increased the level of rare earth elements in semen.
本研究的目的是测量人类精液中镧（La）、铈（Ce）、铕（Eu）和钆（Gd）的浓度，并将结果与精子质量相关联。精液中La的中位数含量为19.5微克/千克干重（dw）（范围为2.27 - 269），Ce为41.9微克/千克dw（范围为4.52至167），Eu为0.68微克/千克dw（范围为0.06 - 1.95），Gd为3.19微克/千克dw（范围为0.38 - 12.0），钙（Ca）为4063毫克/千克dw（范围为484 - 17191）。不饮酒者精液中La、Ce、Eu、Gd和Ca的浓度显著低于饮酒者精液中的浓度。在不饮酒者和适度饮酒者的精液中，La、Ce、Eu、Gd和Ca的浓度存在显著差异。短期吸烟者精液中La、Ce和Gd的浓度显著低于极长期吸烟者。在一组短期吸烟者和一组长期吸烟者的精液中，La浓度也存在显著差异。精液中La、Ce、Eu、Gd和Ca的浓度之间存在正相关。精液中La、Ce、Gd和Ca的浓度与精子的前向运动和正常精子百分比呈正相关。Ca与精子浓度之间存在正相关。La、Ce和Gd的浓度与精子浓度呈负相关，而Ca浓度与射精量呈负相关。在所检测的水平上，La、Ce、Eu和Gd不影响精子质量，而饮酒和吸烟可能会增加精液中稀土元素的含量。
