Otto Schott Institute of Materials Research, Friedrich Schiller University Jena, Fraunhoferstrasse 6, 07743 Jena (Germany) http://www.brauergroup.uni-jena.de.
Angew Chem Int Ed Engl. 2015 Mar 27;54(14):4160-81. doi: 10.1002/anie.201405310. Epub 2015 Mar 12.
Bioactive glasses were the first synthetic materials to show bonding to bone, and they are successfully used for bone regeneration. They can degrade in the body at a rate matching that of bone formation, and through a combination of apatite crystallization on their surface and ion release they stimulate bone cell proliferation, which results in the formation of new bone. Despite their excellent properties and although they have been in clinical use for nearly thirty years, their current range of clinical applications is still small. Latest research focuses on developing new compositions to address clinical needs, including glasses for treating osteoporosis, with antibacterial properties, or for the sintering of scaffolds with improved mechanical stability. This Review discusses how the glass structure controls the properties, and shows how a structure-based design may pave the way towards new bioactive glass implants for bone regeneration.
生物活性玻璃是最早显示与骨结合的合成材料，它们被成功地用于骨再生。它们可以在体内以与骨形成相匹配的速度降解，并且通过表面的磷灰石结晶和离子释放的组合，刺激骨细胞增殖，从而形成新骨。尽管它们具有优异的性能，并且已经在临床应用近三十年，但它们目前的临床应用范围仍然很小。最新的研究重点是开发新的组合物来满足临床需求，包括用于治疗骨质疏松症的玻璃，具有抗菌性能，或用于烧结具有改善机械稳定性的支架。本综述讨论了玻璃结构如何控制性能，并展示了基于结构的设计如何为骨再生的新型生物活性玻璃植入物铺平道路。
