香叶茵芋叶精油的化学成分与生物活性

Ibrar Muhammad, Muhammad Naveed, De Feo Vincenzo

Department of Botany, University of Peshawar, Peshawar 25000, Pakistan.

Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Pakistan.

Molecules. 2015 Mar 16;20(3):4735-45. doi: 10.3390/molecules20034735.

The composition of the essential oil from leaves of Skimmia laureola was determined by GC and GC-MS. Twenty-eight components were identified, accounting for 93.9% of the total oil. The oil is mainly composed of monoterpenes (93.5%), of which monoterpene hydrocarbons and oxygenated monoterpenes represent 11.0% and 82.5%, respectively. Sesquiterpenes constitute only 0.3% of the total oil. Linalyl acetate is the main component (50.5%), with linalool (13.1%), geranyl acetate (8.5%) and cis-p-menth-2-en-1-ol (6.2%) as other principal constituents. The essential oil showed a significant antispasmodic activity, in a dose range of 0.03-10 mg/mL. The essential oil also possesses antibacterial and antifungal activities against some pathogenic strains. The phytotoxic and cytotoxic activities were also assessed.

采用气相色谱（GC）和气相色谱-质谱联用（GC-MS）法测定了香叶茵芋叶精油的成分。共鉴定出28种成分，占精油总量的93.9%。该精油主要由单萜类化合物（93.5%）组成，其中单萜烃类和含氧单萜类分别占11.0%和82.5%。倍半萜类仅占精油总量的0.3%。乙酸芳樟酯是主要成分（50.5%），其他主要成分还有芳樟醇（13.1%）、乙酸香叶酯（8.5%）和顺式-对-薄荷-2-烯-1-醇（6.2%）。该精油在0.03 - 10 mg/mL剂量范围内表现出显著的解痉活性。该精油对一些病原菌还具有抗菌和抗真菌活性。同时也评估了其植物毒性和细胞毒性活性。