Okimoto Satoshi, Yamashita Keiko, Shibata Tetsuo, Kiuchi Yoshiaki
Department of Ophthalmology and Visual science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.
Shibata Eye Clinic, Hyogo, Japan.
PLoS One. 2015 Mar 23;10(3):e0118920. doi: 10.1371/journal.pone.0118920. eCollection 2015.
To compare the optic disc parameters of glaucomatous eyes to those of non-glaucomatous eyes with large discs.
We studied 225 consecutive eyes with large optic discs (>2.82 mm2): 91 eyes with glaucoma and 134 eyes without glaucoma. An eye was diagnosed with glaucoma when visual field defects were detected by the Humphrey Field Analyzer. All of the Heidelberg Retina Tomograph II (HRT II) parameters were compared between the non-glaucomatous and glaucomatous eyes. A logistic regression analysis of the HRT II parameters was used to establish a new formula for diagnosing glaucoma, and the sensitivity and specificity of the Moorfields Regression Analysis (MRA) was compared to the findings made by our analyses.
The mean disc area was 3.44±0.50 mm2 in the non-glaucomatous group and 3.40±0.52 mm2 in the glaucoma group. The cup area, cup volume, cup-to-disc area ratio, linear cup/disc ratio, mean cup depth, and the maximum cup depth were significantly larger in glaucomatous eyes than in the non-glaucomatous eyes. The rim area, rim volume, cup shape measurement, mean retinal nerve fiber layer (RNFL) thickness, and RFNL cross-sectional area were significantly smaller in glaucomatous eyes than in non-glaucomatous eyes. The cup-to-disc area ratio, the height variation contour (HVC), and the RNFL cross-sectional area were important parameters for diagnosing the early stage glaucoma, and the cup-to-disc area ratio and cup volume were useful for diagnosing advanced stage glaucoma in eyes with a large optic disc. The new formula had higher sensitivity and specificity for diagnosing glaucoma than MRA.
The cup-to-disc area ratio, HVC, RNFL cross-sectional area, and cup volume were important parameters for diagnosing glaucoma in eyes with a large optic disc. The important disc parameters to diagnose glaucoma depend on the stage of glaucoma in patients with large discs.
比较青光眼患者与大视盘非青光眼患者的视盘参数。
我们研究了225例连续的大视盘（>2.82 mm²）患者的眼睛：91例青光眼患者和134例非青光眼患者。当通过 Humphrey 视野分析仪检测到视野缺损时，该眼被诊断为青光眼。比较了非青光眼组和青光眼组之间所有海德堡视网膜断层扫描II（HRT II）参数。使用HRT II参数进行逻辑回归分析以建立诊断青光眼的新公式，并将 Moorfields 回归分析（MRA）的敏感性和特异性与我们分析的结果进行比较。
非青光眼组的平均视盘面积为3.44±0.50 mm²，青光眼组为3.40±0.52 mm²。青光眼患者眼中的杯盘面积、杯盘容积、杯盘面积比、线性杯盘比、平均杯盘深度和最大杯盘深度均显著大于非青光眼患者。青光眼患者眼中的视盘边缘面积、视盘边缘容积、杯盘形状测量、平均视网膜神经纤维层（RNFL）厚度和RNFL横截面积均显著小于非青光眼患者。杯盘面积比、高度变化轮廓（HVC）和RNFL横截面积是诊断早期青光眼的重要参数，杯盘面积比和杯盘容积对诊断大视盘眼中的晚期青光眼有用。新公式在诊断青光眼方面比MRA具有更高的敏感性和特异性。
杯盘面积比、HVC、RNFL横截面积和杯盘容积是诊断大视盘眼中青光眼的重要参数。诊断青光眼的重要视盘参数取决于大视盘患者的青光眼阶段。
