Suepaul S M, Carrington C, Campbell M, Borde G, Adesiyun A A
School of Veterinary Medicine, Faculty of Medical Sciences, University of the West Indies, Trinidad.
School of Medicine, Faculty of Medical Sciences, University of the West Indies, St. Augustine, Trinidad and Tobago, West Indies.
Trop Biomed. 2015 Mar;32(1):1-10.
This study determined the antimicrobial susceptibilities of 67 isolates of Leptospira from dogs (suspect canine cases: n=7 and stray dogs: n=6) and rodents (n=54) in Trinidad to 12 antimicrobial agents using broth microdilution and macrodilution techniques. Commonly used antimicrobial agents such as the penicillin G and ceftriaxone had relatively low minimal inhibitory concentrations (MICs) while doxycycline displayed a relatively higher value but was still considered to be effective. While imipenem was the most effective with low MIC values in vitro, sulphamethoxazole-trimethoprim had the highest i.e. least effective. Based on these results, the drugs commonly used in the treatment of leptospirosis (penicillin G, penicillin-streptomycin, doxycycline and ceftriaxone) in both humans and animals in Trinidad appear to have similar MICs and MBCs in vitro when compared with published reports. The serovar of Leptospira spp. and in most cases the origin of the isolates did not significantly (P>0.05) influence their susceptibilities to the antimicrobial agents tested.
本研究采用肉汤微量稀释法和常量稀释法，测定了特立尼达岛67株来自犬类（疑似犬病例：7例和流浪狗：6例）和啮齿动物（54例）的钩端螺旋体对12种抗菌药物的敏感性。常用抗菌药物如青霉素G和头孢曲松的最低抑菌浓度（MIC）相对较低，而多西环素的MIC值相对较高，但仍被认为有效。虽然亚胺培南在体外具有最低的MIC值，是最有效的，但磺胺甲恶唑-甲氧苄啶的MIC值最高，即最无效。基于这些结果，与已发表的报告相比，特立尼达岛人和动物治疗钩端螺旋体病常用的药物（青霉素G、青霉素-链霉素、多西环素和头孢曲松）在体外似乎具有相似的MIC和MBC。钩端螺旋体血清型以及在大多数情况下分离株的来源对其对所测试抗菌药物的敏感性没有显著（P>0.05）影响。
