Goldberg Neil D, Vadlamudi Aravinda, Parrish Nicole
St. Joseph Medical Center, The University of Maryland, Towson, Md., USA.
The Johns Hopkins Medical Institutions, Baltimore, Md., USA.
Case Rep Gastroenterol. 2015 Jan 24;9(1):25-8. doi: 10.1159/000369965. eCollection 2015 Jan-Apr.
The etiology of Crohn's disease (CD) remains controversial. It is hypothesized that CD is the result of an abnormal immune response to the gut flora in genetically susceptible hosts. However, an infectious etiology has not been completely ruled out. Antibiotics have been utilized with some success to modify the course of the disease. Here, we report a patient with CD and pyoderma gangrenosum refractory to standard therapy, including biologics, who achieved remission with a combination of rifaximin, gentamicin and metronidazole.
克罗恩病（CD）的病因仍存在争议。据推测，CD是遗传易感宿主对肠道菌群异常免疫反应的结果。然而，感染性病因尚未被完全排除。抗生素已被用于改变疾病进程并取得了一定成效。在此，我们报告一名患有CD和坏疽性脓皮病的患者，该患者对包括生物制剂在内的标准治疗均无效，而使用利福昔明、庆大霉素和甲硝唑联合治疗后实现了缓解。
