Gerber E, Bernard R, Castang S, Chabot N, Coze F, Dreux-Zigha A, Hauser E, Hivin P, Joseph P, Lazarelli C, Letellier G, Olive J, Leonetti J-P
Deinove, Cap Sigma/ZAC Euromédecine II, Grabels, France.
J Appl Microbiol. 2015 Jul;119(1):1-10. doi: 10.1111/jam.12808. Epub 2015 Apr 20.
Deinococcus spp are among the most radiation-resistant micro-organisms that have been discovered. They show remarkable resistance to a range of damage caused by ionizing radiation, desiccation, UV radiation and oxidizing agents. Traditionally, Escherichia coli and Saccharomyces cerevisiae have been the two platforms of choice for engineering micro-organisms for biotechnological applications, because they are well understood and easy to work with. However, in recent years, researchers have begun using Deinococcus spp in biotechnologies and bioremediation due to their specific ability to grow and express novel engineered functions. More recently, the sequencing of several Deinococcus spp and comparative genomic analysis have provided new insight into the potential of this genus. Features such as the accumulation of genes encoding cell cleaning systems that eliminate organic and inorganic cell toxic components are widespread among Deinococcus spp. Other features such as the ability to degrade and metabolize sugars and polymeric sugars make Deinococcus spp. an attractive alternative for use in industrial biotechnology.
嗜放射球菌属是已发现的最耐辐射的微生物之一。它们对电离辐射、干燥、紫外线辐射和氧化剂造成的一系列损伤表现出显著的抗性。传统上，大肠杆菌和酿酒酵母一直是生物技术应用中工程微生物的两个首选平台，因为它们易于理解且易于操作。然而，近年来，由于嗜放射球菌属具有生长和表达新型工程功能的特定能力，研究人员已开始在生物技术和生物修复中使用它们。最近，几种嗜放射球菌属的测序和比较基因组分析为该属菌（的应用）潜力提供了新的见解。编码消除有机和无机细胞毒性成分的细胞清洁系统的基因积累等特征在嗜放射球菌属中很普遍。其他特征，如降解和代谢糖类及聚合糖的能力，使嗜放射球菌属成为工业生物技术中一个有吸引力的替代选择。
