人T细胞白血病病毒II型感染性克隆的完整核苷酸序列：蛋白酶基因的一个开放阅读框。
Complete nucleotide sequence of an infectious clone of human T-cell leukemia virus type II: an open reading frame for the protease gene.
作者信息
Shimotohno K, Takahashi Y, Shimizu N, Gojobori T, Golde D W, Chen I S, Miwa M, Sugimura T
出版信息
Proc Natl Acad Sci U S A. 1985 May;82(10):3101-5. doi: 10.1073/pnas.82.10.3101.
Abstract
The entire nucleotide sequence of an infectious clone of human T-cell leukemia virus type II provirus was determined. This provirus consists of 8952 nucleotides. In addition to long terminal repeats and gag, pol, env, and X, a protease gene that is responsible for processing the gag precursor protein was found. The protease gene is encoded in a different frame from gag and pol and was located between the gag and pol open reading frames. The 5' region of the protease gene overlaps the 3' gag region. Coding regions of the provirus show about 60% homology with those of human T-cell leukemia virus type I at the nucleotide level. The evolutionary relationship between human T-cell leukemia virus types I and II is discussed.
摘要
确定了人类II型T细胞白血病病毒前病毒感染性克隆的完整核苷酸序列。该前病毒由8952个核苷酸组成。除了长末端重复序列以及gag、pol、env和X基因外，还发现了一个负责加工gag前体蛋白的蛋白酶基因。蛋白酶基因的编码框与gag和pol不同，位于gag和pol开放阅读框之间。蛋白酶基因的5'区域与gag的3'区域重叠。前病毒的编码区在核苷酸水平上与人I型T细胞白血病病毒的编码区显示出约60%的同源性。讨论了人I型和II型T细胞白血病病毒之间的进化关系。
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