Boden G, Wilson R M, Essa-Koumar N, Owen O E
Gut. 1978 Apr;19(4):277-83. doi: 10.1136/gut.19.4.277.
We have studied the effect of a protein meal on secretin (IRS) concentration in dogs and humans using a radioimmunoassay of improved sensitivity (8 pg/ml). After a meal, pancreatic bicarbonate secretion (PBS) increased markedly and proximal duodenal pH decreased from 6.2 to 4.3. Portal and peripheral IRS concentrations, however, remained unchanged in eight dogs and five patients with cirrhosis of the liver. Similarly, an alkaline solution of sodium oleate (pH 9.2) stimulated PBS but not IRS. Intraduodenal administration of various amounts of HCl in dogs demonstrated that acid-stimulated PBS was invariably accompanied by rises in peripheral venous IRS concentration. We conclude that the postprandial stimulation of PBS involves mechanisms more complex than acid-stimulated secretin release.
我们使用灵敏度更高（8皮克/毫升）的放射免疫分析法，研究了蛋白质餐对犬类和人类中促胰液素（IRS）浓度的影响。进食后，胰腺碳酸氢盐分泌（PBS）显著增加，十二指肠近端pH值从6.2降至4.3。然而，在8只犬和5例肝硬化患者中，门静脉和外周血IRS浓度保持不变。同样，油酸钠碱性溶液（pH 9.2）刺激了PBS，但未刺激IRS。在犬类中十二指肠内给予不同量的盐酸表明，酸刺激的PBS总是伴随着外周静脉IRS浓度的升高。我们得出结论，餐后对PBS的刺激涉及比酸刺激促胰液素释放更复杂的机制。
