Azza Zora, Oudghiri Mounia
Department of Biology, Faculty of Sciences Ain Chock, Laboratory of Physiology and Molecular Genetics, Immunology Unit, University Hassan II, B.P. 5366, Mâarif, Casablanca, Morocco.
Pharmacognosy Res. 2015 Apr-Jun;7(2):213-6. doi: 10.4103/0974-8490.150510.
The aerial parts of Thymelaea hirsuta (TH) are used as a decoction in the treatment of different pathologies in folk medicine in Morocco.
The aqueous extracts were evaluated for its anti-inflammatory activity and in inhibition of adjuvant induction arthritis in male Wistar rats.
The anti-inflammatory activity was carried out using carrageenan-induced rat paw edema model, and the antiarthritic activity was carried out using complete Freund's adjuvant-induced arthritis model.
The plant extract (500 mg/kg body weight) exhibited significant activity in acute inflammation produced 60% of inhibition after 4 h as compared with that of the standard anti-inflammatory drug, the diclofenac (100 mg/kg) which showed 40% of inhibition. In arthritis model, the extract produced 85% inhibition after 18 days when compared with the diclofenac (10 mg/kg; 72%).
These results indicate that the aqueous extract of TH had an anti-inflammatory activity and inhibited the induction of adjuvant arthritis in male Wistar rats.
在摩洛哥民间医学中，多毛瑞香（TH）的地上部分被用作煎剂来治疗各种病症。
评估水提取物对雄性Wistar大鼠的抗炎活性及对佐剂诱导性关节炎的抑制作用。
采用角叉菜胶诱导的大鼠足肿胀模型进行抗炎活性实验，采用完全弗氏佐剂诱导的关节炎模型进行抗关节炎活性实验。
与标准抗炎药双氯芬酸（100mg/kg，抑制率40%）相比，植物提取物（500mg/kg体重）在急性炎症中表现出显著活性，4小时后抑制率达60%。在关节炎模型中，与双氯芬酸（10mg/kg，抑制率72%）相比，提取物在18天后的抑制率为85%。
这些结果表明，TH水提取物具有抗炎活性，并能抑制雄性Wistar大鼠佐剂性关节炎的诱导。
