Bowen Leah K, Hands Gabrielle L, Pradhan Sujata, Stepp Cara E
Biomedical Engineering, Northwestern University, Evanston, IL.
Speech, Language, & Hearing Sciences, Boston University, Boston, MA.
J Med Speech Lang Pathol. 2013 Sep;21(3):235-244.
In Parkinson's Disease (PD), qualitative speech changes such as decreased variation in pitch and loudness are common, but quantitative vocal changes are not well documented. The variability of fundamental frequency (F0) in 32 individuals (23 male) with PD both ON and OFF levodopa medication was compared with 32 age-matched healthy controls (23 male). Participants read a single paragraph and estimates of fundamental frequency (F0) variability were determined for the entire reading passage as well as for the first and last sentences of the passage separately. F0 variability was significantly increased in controls relative to both PD groups and PD patients showed significantly higher F0 variability while ON medication relative to OFF. No significant effect of group was seen in the change in F0 variability from the beginning to the end of the reading passage. Female speakers were found to have higher F0 variability than males. F0 variability was both significantly reduced in PD relative to controls and significantly increased in patients with PD during use of dopaminergic medications. F0 variability changes over the course of reading a paragraph may not be indicative of PD but rather dependent on non-disease factors such as the linguistic characteristics of the text.
在帕金森病（PD）中，诸如音高和响度变化减少等言语质量变化很常见，但定量的嗓音变化记录并不充分。将32名帕金森病患者（23名男性）在服用左旋多巴药物“开”和“关”状态下的基频（F0）变异性与32名年龄匹配的健康对照者（23名男性）进行比较。参与者阅读一段文字，并分别确定整个阅读段落以及段落的第一句和最后一句的基频（F0）变异性估计值。与两个帕金森病组相比，对照组的F0变异性显著增加，并且帕金森病患者在服药“开”状态下的F0变异性相对于“关”状态显著更高。从阅读段落开始到结束，F0变异性的变化在组间未观察到显著影响。发现女性说话者的F0变异性高于男性。相对于对照组，帕金森病患者的F0变异性显著降低，而在使用多巴胺能药物期间，帕金森病患者的F0变异性显著增加。阅读一段文字过程中F0变异性的变化可能并不表明患有帕金森病，而是取决于非疾病因素，如文本的语言特征。
