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传统草药方剂半夏泻心汤在 RAW 264.7 巨噬细胞和 HaCaT 角质形成细胞中发挥抗炎作用。

Traditional Herbal Formula Banhasasim-tang Exerts Anti-Inflammatory Effects in RAW 264.7 Macrophages and HaCaT Keratinocytes.

机构信息

Herbal Medicine Formulation Research Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 305-811, Republic of Korea.

Herbal Medicine Formulation Research Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 305-811, Republic of Korea ; Division of Allergy and Chronic Respiratory Diseases, Center for Biomedical Sciences, Korea National Institute of Health, Chungcheongbuk-do 361-951, Republic of Korea.

出版信息

Evid Based Complement Alternat Med. 2015;2015:728380. doi: 10.1155/2015/728380. Epub 2015 Mar 9.

DOI:10.1155/2015/728380
PMID:25838833
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4369961/
Abstract

Banhasasim-tang (BHSST) is a Korean traditional herbal formula comprising eight medicinal herbs. The aim of the present study was to investigate the anti-inflammatory effect of BHSST using macrophage and keratinocyte cell lines. First, we evaluated the effects of BHSST on inflammatory mediator and cytokine production in lipopolysaccharide- (LPS-) stimulated RAW 264.7 macrophages. BHSST markedly inhibited the production of nitric oxide (NO), prostaglandin E2 (PGE2), and interleukin- (IL-) 6. BHSST significantly suppressed the protein expression of toll-like receptor 4 (TLR4) and phosphorylated nuclear factor-kappa B (NF-κB) p65 in RAW 264.7 cells. Second, we examined whether BHSST influences the production of chemokines and STAT1 phosphorylation in tumor necrosis factor-α/interferon-γ TI-stimulated HaCaT keratinocytes. BHSST significantly suppressed the production of RANTES/CCL5, TARC/CCL17, MDC/CCL22, and IL-8 in TI-stimulated HaCaT cells. BHSST also suppressed TI-induced phosphorylation of STAT1 in HaCaT cells. These results suggest that BHSST may be useful as an anti-inflammatory agent, especially for inflammatory skin diseases.

摘要

百花散汤（BHSST）是一种由八种草药组成的韩国传统草药配方。本研究旨在通过巨噬细胞和角质形成细胞系研究 BHSST 的抗炎作用。首先，我们评估了 BHSST 对脂多糖（LPS）刺激的 RAW 264.7 巨噬细胞中炎症介质和细胞因子产生的影响。BHSST 显著抑制一氧化氮（NO）、前列腺素 E2（PGE2）和白细胞介素-（IL-）6 的产生。BHSST 显著抑制 RAW 264.7 细胞中 TLR4 和磷酸化核因子-κB（NF-κB）p65 的蛋白表达。其次，我们研究了 BHSST 是否影响肿瘤坏死因子-α/干扰素-γ（TI）刺激的 HaCaT 角质形成细胞中趋化因子的产生和 STAT1 磷酸化。BHSST 显著抑制 TI 刺激的 HaCaT 细胞中 RANTES/CCL5、TARC/CCL17、MDC/CCL22 和 IL-8 的产生。BHSST 还抑制了 TI 诱导的 HaCaT 细胞中 STAT1 的磷酸化。这些结果表明，BHSST 可用作抗炎剂，特别是用于炎症性皮肤病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3719/4369961/3a544e2c0a89/ECAM2015-728380.008.jpg
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