1 Department of Internal Medicine, School of Medicine, Pusan National University, Busan, Republic of Korea.
2 Medical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.
Chron Respir Dis. 2019 Jan-Dec;16:1479972318775422. doi: 10.1177/1479972318775422. Epub 2018 May 9.
The quality of life of patients with chronic obstructive pulmonary disease (COPD) decreases significantly as the disease progresses; those with severe COPD are affected most. This article investigates predictors of the disease-specific and generic health-related quality of life (HRQL) in patients with severe COPD. This multicentre prospective cross-sectional study enrolled 80 patients with severe COPD. At enrolment, all patients completed a disease-specific instrument, the St George's Respiratory Questionnaire (SGRQ), and a generic instrument, the Short Form 36 Health Survey Questionnaire (SF-36). The data were analyzed by Pearson's correlation and multiple linear regression. The mean age of the patients was 66 ± 8 years; 93% were males. The SGRQ and SF-36 scores were not influenced by age or sex. Depression, dyspnea, the number of exacerbations, and exercise capacity significantly predicted the total SGRQ score ( p < 0.05). Depression was the strongest determinant of the total SGRQ score. The SF-36 physical component summary scores were related to depression, dyspnea, and the number of exacerbations ( p < 0.05). In comparison, the SF-36 mental component summary scores were related to depression and anxiety ( p < 0.05). Depression is a significant determinant of both the disease-specific and generic HRQL in patients with severe COPD. Screening and early intervention for depression in patients with severe COPD could improve the HRQL.
慢性阻塞性肺疾病（COPD）患者的生活质量随着疾病的进展显著下降；严重 COPD 患者受影响最大。本文研究了严重 COPD 患者疾病特异性和通用健康相关生活质量（HRQL）的预测因素。这项多中心前瞻性横断面研究纳入了 80 名严重 COPD 患者。在入组时，所有患者都完成了一个疾病特异性工具，圣乔治呼吸问卷（SGRQ）和一个通用工具，36 项简短健康调查问卷（SF-36）。通过 Pearson 相关性和多元线性回归分析数据。患者的平均年龄为 66 ± 8 岁；93%为男性。SGRQ 和 SF-36 评分不受年龄或性别影响。抑郁、呼吸困难、加重次数和运动能力显著预测了 SGRQ 总分（p < 0.05）。抑郁是 SGRQ 总分的最强决定因素。SF-36 生理成分综合评分与抑郁、呼吸困难和加重次数有关（p < 0.05）。相比之下，SF-36 心理成分综合评分与抑郁和焦虑有关（p < 0.05）。抑郁是严重 COPD 患者疾病特异性和通用 HRQL 的重要决定因素。对严重 COPD 患者进行抑郁筛查和早期干预可以改善 HRQL。
