Shearman C P, Gosling P, Walker K J
Department of Surgery, University of Birmingham.
J Clin Pathol. 1989 Nov;42(11):1132-5. doi: 10.1136/jcp.42.11.1132.
Serial six hourly urine collections were made for seven days on 20 patients with acute pancreatitis. Quantitative immunoassay of urinary albumin and IgG on the first urine sample after admission showed increased excretion rates in 14 and 13 patients, respectively. Urinary protein excretion rates remained normal or approached normal by seven days in 17 patients who made uneventful recoveries. The maximum urinary excretion rates of both albumin and IgG within the first 36 hours correlated with the serum C-reactive protein concentration 72 hours after admission. The highest IgG excretion rates were found in three patients who later developed severe complications. These preliminary data suggest that low proteinuria is a very early response in acute pancreatitis, and that it may reflect the severity of inflammation.
对20例急性胰腺炎患者连续7天每6小时收集一次尿液。入院后首个尿液样本中尿白蛋白和IgG的定量免疫分析显示，分别有14例和13例患者排泄率升高。17例顺利康复的患者在7天时尿蛋白排泄率保持正常或接近正常。入院后36小时内白蛋白和IgG的最大尿排泄率与72小时后的血清C反应蛋白浓度相关。在3例后来出现严重并发症的患者中发现了最高的IgG排泄率。这些初步数据表明，低蛋白尿是急性胰腺炎非常早期的反应，并且可能反映炎症的严重程度。
