Franklin Nina C, Robinson Austin T, Bian Jing-Tan, Ali Mohamed M, Norkeviciute Edita, McGinty Patrick, Phillips Shane A
1 Department of Physical Therapy, University of Illinois at Chicago , Chicago, Illinois.
Metab Syndr Relat Disord. 2015 Jun;13(5):227-34. doi: 10.1089/met.2014.0135. Epub 2015 Apr 6.
Cardiovascular disease (CVD) is a leading cause of preventable death among young women in the United States. Habitual resistance exercise training is known to have beneficial effects on endothelial function and CVD risk factors, including obesity; however, previous studies show that acute resistance exercise impairs endothelial function in obese adults who are sedentary, a response that may be linked to inflammation. We sought to determine if circuit-based resistance training (CRT) attenuates acute resistance exercise-induced reductions in endothelial function in a population of young, obese, sedentary women and whether or not inflammation plays a role in this response.
Eighteen obese [body mass index (BMI) 30.0-40.0 kg · m(-2)] young premenopausal women were randomly assigned to either a CRT group or a no-exercise control group (CON). Conduit artery endothelial function was assessed using brachial artery flow-mediated dilation (FMD) determined by ultrasound before and after a single bout of strenuous weightlifting (SWL). In addition, circulating inflammatory mediators (tumor necrosis factor-α and C-reactive protein), blood pressure, fasting blood lipids, glucose, waist circumference, body composition, and aerobic capacity were assessed.
Among participants randomized to the CRT group, 8 weeks of training led to considerable increases in FMD after SWL (P=0.001) compared to the CON group. However, no significant differences between the groups were observed in circulating inflammatory mediators, blood pressure, fasting blood lipids, or other physical and physiological characteristics.
This study shows that CRT alleviates acute exertion-induced reductions in endothelial function among obese sedentary women in the absence of changes in inflammation.
心血管疾病（CVD）是美国年轻女性可预防死亡的主要原因。习惯性抗阻运动训练已知对内皮功能和包括肥胖在内的心血管疾病风险因素具有有益影响；然而，先前的研究表明，急性抗阻运动可损害久坐不动的肥胖成年人的内皮功能，这种反应可能与炎症有关。我们试图确定基于循环的抗阻训练（CRT）是否能减轻急性抗阻运动引起的年轻、肥胖、久坐女性内皮功能的降低，以及炎症是否在这种反应中起作用。
18名肥胖（体重指数BMI为30.0 - 40.0 kg·m⁻²）的绝经前年轻女性被随机分为CRT组或无运动对照组（CON）。在单次剧烈举重（SWL）前后，通过超声测定肱动脉血流介导的舒张功能（FMD）来评估导管动脉内皮功能。此外，还评估了循环炎症介质（肿瘤坏死因子-α和C反应蛋白）、血压、空腹血脂、血糖、腰围、身体成分和有氧能力。
与CON组相比，随机分配到CRT组的参与者经过8周训练后，SWL后FMD显著增加（P = 0.001）。然而，两组在循环炎症介质、血压、空腹血脂或其他身体和生理特征方面未观察到显著差异。
本研究表明，在炎症无变化的情况下，CRT可减轻肥胖久坐女性急性运动引起的内皮功能降低。
