Schneider M
Poliklinik und Funktionsbereich für Rheumatologie UKD, Heinrich-Heine-Universität Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Deutschland,
Z Rheumatol. 2015 Apr;74(3):199-205. doi: 10.1007/s00393-014-1457-1.
Therapeutic strategy means the definition of a long-term target, which should be reached by a chosen management. As for rheumatoid arthritis, the treat to target initiative recommends remission as the target for systemic lupus erythematosus (SLE) but the command variables of remission are not yet defined. The basis of a therapeutic strategy is first the analysis of those factors that may influence the achievement of the objectives: SLE disease activity, the differentiation of damage, organ manifestations, comorbidities, genetics, sex, age of onset and considering the pathophysiological basis are some of these factors. The next step is the analysis of the available substances and concepts that allow the target to be reached. Finally, rules for management (e.g. guidelines) are needed that enrich the possibility to reach the target and improve the prognosis of patients suffering from SLE.
治疗策略是指确定一个长期目标，该目标应由选定的治疗方案来实现。对于类风湿性关节炎，“达标治疗”倡议推荐将缓解作为系统性红斑狼疮（SLE）的治疗目标，但缓解的控制变量尚未明确。治疗策略的基础首先是分析那些可能影响目标实现的因素：SLE疾病活动度、损伤的分化、器官表现、合并症、遗传学、性别、发病年龄，而考虑病理生理基础也是其中一些因素。下一步是分析可用于实现目标的现有药物和理念。最后，需要管理规则（如指南），以增加实现目标的可能性，并改善SLE患者的预后。
