Fang Sijie, Deng Yuan, Gu Ping, Fan Xianqun
Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, China.
Int J Mol Sci. 2015 Apr 13;16(4):8227-53. doi: 10.3390/ijms16048227.
MicroRNAs (miRNAs) are endogenous small noncoding ~22-nt RNAs, which have been reported to play a crucial role in maintaining bone development and metabolism. Osteogenesis originates from mesenchymal stem cells (MSCs) differentiating into mature osteoblasts and each period of bone formation is inseparable from the delicate regulation of various miRNAs. Of note, apprehending the sophisticated circuit between miRNAs and osteogenic homeostasis is of great value for artificial skeletal regeneration for severe bone defects. In this review, we highlight how different miRNAs interact with diverse osteo-related genes and endeavor to sketch the contours of potential manipulations of miRNA-modulated bone repair.
微小RNA（miRNA）是内源性的约22个核苷酸的小非编码RNA，据报道在维持骨骼发育和代谢中起关键作用。骨生成起源于间充质干细胞（MSC）分化为成熟的成骨细胞，并且骨形成的每个阶段都离不开各种miRNA的精细调节。值得注意的是，了解miRNA与成骨稳态之间的复杂机制对于严重骨缺损的人工骨再生具有重要价值。在本综述中，我们重点介绍了不同的miRNA如何与多种骨相关基因相互作用，并试图勾勒出miRNA调控骨修复的潜在操作轮廓。
