Haryanto Haryanto, Urai Tamae, Mukai Kanae, Gontijo Filho Paulo P, Suriadi Suriadi, Sugama Junko, Nakatani Toshio
Department of Clinical Nursing, Graduate School of Medical Science, Kanazawa University, Japan; Institute of Nursing, Muhammadiyah Pontianak, Indonesia; email:
Department of Clinical Nursing, Graduate School of Medical Science, Kanazawa University, Japan.
Wounds. 2012 Apr;24(4):110-9.
The purpose of this study was to investigate the effectiveness of Indonesian honey in wound healing compared to Tegaderm hydrocolloid dressing and Manuka honey. Three groups of male mice were treated to produce 2 circular, full-thickness skin wounds on the dorsum. They were then randomly allocated to receive daily Indonesian honey, Manuka honey, or hydrocolloid (control). Macroscopic findings were observed from day 0 to 14 after wounding. Microscopic findings on days 3, 7, 11, and 14 after wounding were obtained. The ratios of wound areas for honey groups on day 3 were smaller than those of the control group. Wound areas of honey groups gradually decreased to almost the same wound area as the control group on day 14, while the control group wound area peaked on day 5 and rapidly decreased until day 14. On day 3, myofibroblasts and new blood capillaries in wound tissue of honey groups were observed, but were not seen in the control group. After day 7, microscopic findings were almost the same among the 3 groups. These results indicate that Indonesian honey is almost as effective for wound healing as Manuka honey and hydrocolloid dressing. .
本研究的目的是调查与德湿可水胶体敷料和麦卢卡蜂蜜相比，印尼蜂蜜在伤口愈合方面的有效性。将三组雄性小鼠进行处理，使其背部产生2个圆形的全层皮肤伤口。然后将它们随机分配，分别每日接受印尼蜂蜜、麦卢卡蜂蜜或水胶体（对照组）治疗。在受伤后第0天至第14天观察宏观结果。获取受伤后第3天、第7天、第11天和第14天的微观结果。蜂蜜组在第3天的伤口面积比例小于对照组。蜂蜜组的伤口面积在第14天逐渐减小至与对照组几乎相同，而对照组的伤口面积在第5天达到峰值，并迅速减小直至第14天。在第3天，观察到蜂蜜组伤口组织中有肌成纤维细胞和新的毛细血管，但对照组中未观察到。第7天后，三组的微观结果几乎相同。这些结果表明，印尼蜂蜜在伤口愈合方面的效果几乎与麦卢卡蜂蜜和水胶体敷料相同。
