Graduate Course of Nursing Science, Division of Health Sciences, Department of Clinical Nursing, Graduate School of Medical Science, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa 920-0942, Japan.
Evid Based Complement Alternat Med. 2013;2013:504537. doi: 10.1155/2013/504537. Epub 2013 Jan 20.
Although many previous studies reported that honey promotes wound healing, no study has examined the effects of Japanese honey. The aim of this study was to investigate the effects of three types of Japanese honey, Acacia, Buckwheat flour, and Chinese milk vetch honey, on wound healing in comparison with hydrocolloid dressing. Circular full-thickness skin wounds were produced on male mice. Japanese honey or hydrocolloid dressing was applied daily to the mice for 14 days. The ratio of wound area for the hydrocolloid dressing group increased initially in the inflammatory and early proliferative phases and then decreased rapidly to heal with scarring. However, the ratios of wound area for the Japanese honey groups decreased in the inflammatory phase, increased in the proliferative phase, and decreased in the proliferative phase, and some wounds were not completely covered with new epithelium. These findings indicate that using Japanese honey alone has limited benefit, but since it reduces wound size in the inflammatory phase, it is possible to apply a combined treatment in which Japanese honey is applied only in the inflammatory phase, followed by hydrocolloid dressing from the proliferative phase, which would effectively contract the wound.
尽管许多先前的研究报告称蜂蜜有助于伤口愈合，但没有研究检查过日本蜂蜜的影响。本研究旨在比较三种日本蜂蜜（洋槐蜜、荞麦粉蜜和紫云英蜜）与水胶体敷料对伤口愈合的影响。在雄性小鼠上制造圆形全层皮肤伤口。每天向小鼠施用日本蜂蜜或水胶体敷料 14 天。水胶体敷料组的伤口面积比例在炎症和早期增殖阶段最初增加，然后迅速减少以瘢痕愈合。然而，日本蜂蜜组的伤口面积比例在炎症阶段下降，在增殖阶段增加，并且在增殖阶段下降，一些伤口没有完全被新上皮覆盖。这些发现表明单独使用日本蜂蜜益处有限，但由于它可以减轻炎症阶段的伤口大小，因此可以采用联合治疗，即在炎症阶段仅使用日本蜂蜜，然后从增殖阶段开始使用水胶体敷料，这可以有效地收缩伤口。
