Department of Clinical Nursing, Graduate Course of Nursing Science, Division of Health Sciences, Graduate School of Medical Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa 920-0942, Japan.
Department of Nursing, School of Health Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa 920-0942, Japan.
Evid Based Complement Alternat Med. 2015;2015:910605. doi: 10.1155/2015/910605. Epub 2015 Apr 7.
The aim of this study was to evaluate the effect of the combined use of Japanese honey and hydrocolloid dressing (HCD) on cutaneous wound healing. Mice were divided into four groups: the Acacia (Japan) + HCD, Manuka (New Zealand) + HCD, Chinese milk vetch (Japan) + HCD, and HCD (control) groups. The mice received two full-thickness wounds. The wounds of the HCD group were covered with HCD, whereas those of the other groups were treated with 0.1 mL of the relevant type of honey, before being covered with HCD. Wound area was significantly smaller in the HCD group than in the Acacia + HCD and Manuka + HCD groups on day 13 and days 8-14, respectively. Moreover, compared with the HCD group, reepithelialization was delayed in the Acacia + HCD group and reepithelialization and collagen deposition were delayed in the Chinese milk vetch + HCD and Manuka + HCD groups. These results indicate that the combined use of Japanese honey and HCD does not promote cutaneous wound healing compared with the use of HCD alone. Thus, this method is probably not useful for promoting healing.
本研究旨在评估日本蜂蜜和水胶体敷料（HCD）联合使用对皮肤伤口愈合的影响。将小鼠分为四组：相思树（日本）+HCD、麦卢卡（新西兰）+HCD、紫云英（日本）+HCD 和 HCD（对照）组。每组小鼠均接受两个全层皮肤伤口。HCD 组的伤口用 HCD 覆盖，而其他组的伤口先用 0.1ml 相关类型的蜂蜜处理，然后再用 HCD 覆盖。第 13 天和第 8-14 天，HCD 组的伤口面积明显小于相思树+HCD 和麦卢卡+HCD 组。此外，与 HCD 组相比，相思树+HCD 组的上皮化延迟，而紫云英+HCD 和麦卢卡+HCD 组的上皮化和胶原沉积延迟。这些结果表明，与单独使用 HCD 相比，日本蜂蜜和 HCD 的联合使用并没有促进皮肤伤口愈合。因此，这种方法可能对促进愈合没有帮助。
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