Chen Ting, Wang Fengyun, Chu Zhenyu, Shi Xiaoyan, Sun Ling, Lv Haitao, Zhou Wanping, Shen Jie, Chen Linqi, Hou Miao
Department of Endocrinology, Metabolism and Genetic Disorders, Children's Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China.
Department of Emergency Intensive Care Unit, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China.
Diabetes Metab Syndr Obes. 2019 Sep 20;12:1923-1930. doi: 10.2147/DMSO.S222066. eCollection 2019.
CTRP3 is a novel peptide that has recently emerged as an important regulatory adipokine of obesity and related metabolic disease. Little is known about its role in children. The current study aimed to investigate the potential role of CTRP3 in obese children and explore its relationships with insulin sensitivity, pancreatic β cell function, and obesity-related markers.
We studied the levels of serum CTRP3 in 48 obese and 36 normal weight pre-puberty children. The levels of blood pressure, lipids, glucose, and insulin were measured, and the values of HOMA-IR, HOMA-β and insulinogenic index were calculated. The correlations of these measurements with CTRP3 levels were analyzed.
In this study, we found that CTRP3 serum levels significantly decreased in obese children compared to controls, and insulin resistant obese subjects have lower CTRP3 levels in contrast with the non-insulin resistant obese subjects. Moreover, serum CTRP3 concentrations significantly decreased, while glucose and insulin concentrations significantly increased after a 3 hrs oral glucose tolerance test in obese children. Furthermore, Serum CTRP3 levels correlated negatively and significantly with BMI, triglycerides, systolic blood pressure, fasting insulin, glucose, HOMA-IR, HOMA-β and insulinogenic index in obese children.
In summary, serum CTRP3 levels significantly decreased in obese children, and negatively correlated with insulin resistance and pancreatic β cell function indicators. Therefore, CTRP3 may play a protective role in the glucose homeostasis and tightly related to β cell function as well as obesity-related markers in obese children.
CTRP3是一种新型肽，最近已成为肥胖及相关代谢疾病的重要调节性脂肪因子。关于其在儿童中的作用知之甚少。本研究旨在探讨CTRP3在肥胖儿童中的潜在作用，并探索其与胰岛素敏感性、胰腺β细胞功能及肥胖相关标志物的关系。
我们研究了48名肥胖和36名正常体重的青春期前儿童的血清CTRP3水平。测量了血压、血脂、血糖和胰岛素水平，并计算了HOMA-IR、HOMA-β和胰岛素生成指数的值。分析了这些测量值与CTRP3水平的相关性。
在本研究中，我们发现肥胖儿童的CTRP3血清水平与对照组相比显著降低，与非胰岛素抵抗肥胖受试者相比，胰岛素抵抗肥胖受试者的CTRP3水平更低。此外，肥胖儿童口服葡萄糖耐量试验3小时后，血清CTRP3浓度显著降低，而血糖和胰岛素浓度显著升高。此外，肥胖儿童的血清CTRP3水平与BMI、甘油三酯、收缩压、空腹胰岛素、血糖、HOMA-IR、HOMA-β和胰岛素生成指数呈显著负相关。
总之，肥胖儿童的血清CTRP3水平显著降低，且与胰岛素抵抗和胰腺β细胞功能指标呈负相关。因此，CTRP3可能在肥胖儿童的葡萄糖稳态中起保护作用，并与β细胞功能以及肥胖相关标志物密切相关。
