3,5,6,7,8,3',4'-七甲氧基黄酮，一种柑橘多甲氧基黄酮，可减轻小鼠海马体的炎症。

Department of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan.

Department of Pharmacognosy, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan.

Brain Sci. 2015 Apr 15;5(2):118-29. doi: 10.3390/brainsci5020118.

Citrus polymethoxylated flavones (PMFs) have recently been shown to suppress inflammation in peripheral tissues. In the present study, we investigated the effects of 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF), one of the PMFs, on inflammation in the brain in vivo using mice injected intrahippocampally with lipopolysaccharide (LPS). We demonstrated that subcutaneously injected HMF suppressed: (1) LPS-induced losses in body weight; (2) LPS-induced microglial activation in the hippocampus; and (3) LPS-induced interleukin-1β mRNA expression in the hippocampus. These results suggest that HMF has the ability to reduce neuroinflammation in the brain.

柑橘多甲氧基黄酮（PMFs）最近被证明可以抑制外周组织的炎症。在本研究中，我们使用向海马内注射脂多糖（LPS）的小鼠，在体内研究了 3,5,6,7,8,3',4'-七甲氧基黄酮（HMF）等 PMFs 对大脑炎症的影响。我们证明，皮下注射 HMF 抑制了：（1）LPS 诱导的体重下降；（2）LPS 诱导的海马小胶质细胞活化；（3）LPS 诱导的海马白细胞介素-1β mRNA 表达。这些结果表明，HMF 具有减轻大脑神经炎症的能力。