University of WA, Department of Chemical Engineering, Seattle, USA.
University of WA, Department of Bioengineering, Seattle, USA.
Adv Drug Deliv Rev. 2015 Aug 30;91:23-37. doi: 10.1016/j.addr.2015.04.008. Epub 2015 Apr 17.
Despite intensive surgical excision, radiation therapy, and chemotherapy, the current life expectancy for patients diagnosed with glioblastoma multiforme is only 12 to 15months. One of the approaches being explored to increase chemotherapeutic efficacy is to locally deliver chemotherapeutics encapsulated within degradable, polymeric microspheres. This review describes the techniques used to formulate drug encapsulated microspheres targeted for intracranial tumor therapy and how microsphere characteristics such as drug loading and encapsulation efficiency can be tuned based on formulation parameters. Further, the results of in vitro studies are discussed, detailing the varied drug release profiles obtained and validation of drug efficacy. Finally, in vivo results are summarized, highlighting the study design and the effectiveness of the drug encapsulated microspheres applied intracranially.
尽管进行了密集的手术切除、放射治疗和化疗，被诊断患有多形性胶质母细胞瘤的患者的预期寿命仍只有 12 到 15 个月。为了提高化疗效果，人们正在探索的方法之一是局部递送包封在可降解聚合物微球中的化疗药物。这篇综述描述了用于制备针对颅内肿瘤治疗的药物包封微球的技术，以及如何根据制剂参数调整微球的特性，如载药量和包封效率。此外，还讨论了体外研究的结果，详细说明了所获得的不同药物释放曲线，并验证了药物的疗效。最后，总结了体内研究的结果，突出了药物包封微球的颅内应用的研究设计和效果。
