糖缀合物功能化磁性纳米颗粒作为强效抗粘附剂用于减少产肠毒素大肠杆菌感染的合成与应用
Synthesis and application of glycoconjugate-functionalized magnetic nanoparticles as potent anti-adhesion agents for reducing enterotoxigenic Escherichia coli infections.
作者信息
Raval Yash S, Stone Roland, Fellows Benjamin, Qi Bin, Huang Guohui, Mefford O Thompson, Tzeng Tzuen-Rong J
机构信息
Department of Biological Sciences, Clemson University, Clemson, SC 29634, USA.
出版信息
Nanoscale. 2015 May 14;7(18):8326-31. doi: 10.1039/c5nr00511f.
Polyethylene oxide stabilized magnetic nanoparticles (PEO-MNPs) bio-functionalized with glycoconjugate (Neu5Ac(α2-3)Gal(β1-4)Glcβ-sp) (GM3-MNPs) are synthesized using click chemistry. Interaction of GM3-MNPs with Enterotoxigenic Escherichia coli (ETEC) strain K99 (EC K99) is investigated using different microscopic techniques. Our results suggest that GM3-MNPs can effectively act as non-antibiotic anti-adhesion agents for treating ETEC infections.
采用点击化学合成了用糖缀合物（Neu5Ac(α2-3)Gal(β1-4)Glcβ-sp）（GM3-MNPs）进行生物功能化的聚环氧乙烷稳定磁性纳米颗粒（PEO-MNPs）。使用不同的显微镜技术研究了GM3-MNPs与产肠毒素大肠杆菌（ETEC）菌株K99（EC K99）的相互作用。我们的结果表明，GM3-MNPs可有效作为非抗生素抗粘附剂用于治疗ETEC感染。
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