Raval Yash S, Stone Roland, Fellows Benjamin, Qi Bin, Huang Guohui, Mefford O Thompson, Tzeng Tzuen-Rong J
Department of Biological Sciences, Clemson University, Clemson, SC 29634, USA.
Nanoscale. 2015 May 14;7(18):8326-31. doi: 10.1039/c5nr00511f.
Polyethylene oxide stabilized magnetic nanoparticles (PEO-MNPs) bio-functionalized with glycoconjugate (Neu5Ac(α2-3)Gal(β1-4)Glcβ-sp) (GM3-MNPs) are synthesized using click chemistry. Interaction of GM3-MNPs with Enterotoxigenic Escherichia coli (ETEC) strain K99 (EC K99) is investigated using different microscopic techniques. Our results suggest that GM3-MNPs can effectively act as non-antibiotic anti-adhesion agents for treating ETEC infections.
采用点击化学合成了用糖缀合物（Neu5Ac(α2-3)Gal(β1-4)Glcβ-sp）（GM3-MNPs）进行生物功能化的聚环氧乙烷稳定磁性纳米颗粒（PEO-MNPs）。使用不同的显微镜技术研究了GM3-MNPs与产肠毒素大肠杆菌（ETEC）菌株K99（EC K99）的相互作用。我们的结果表明，GM3-MNPs可有效作为非抗生素抗粘附剂用于治疗ETEC感染。
