2009 年 H1N1 大流行期间，密歇根州反应性学校关闭对社区流感样病例数的影响。
The effect of reactive school closure on community influenza-like illness counts in the state of Michigan during the 2009 H1N1 pandemic.
机构信息
Epidemiology Department, University of Michigan School of Public Health.
Center for the History of Medicine, University of Michigan Medical School, Ann Arbor.
出版信息
Clin Infect Dis. 2015 Jun 15;60(12):e90-7. doi: 10.1093/cid/civ182. Epub 2015 Apr 20.
BACKGROUND
In sum, 559 Michigan schools were closed as a nonpharmaceutical intervention during the influenza A 2009 (H1N1) pandemic.
METHODS
By linking the proportion of schools closed within a district to state influenza-like illness (ILI) surveillance data, we measured its effect on community levels of ILI. This analysis was centered by the peak week of ILI for each school district, and a negative binomial model compared three levels of school closure: 0%, 1%-50%, and 51%-100% of schools closed from three weeks leading up to ILI peak to four weeks following ILI peak rate.
RESULTS
We observed that school closures were reactive, and there was no statistically significant difference between ILI rates over the study period. There was an elevated rate ratio for ILI at 51%-100% closure, and a reduction in the rate ratio at the 1%-50% compared to the 0% closure level.
CONCLUSIONS
These findings suggest that district level reactive school closures were ineffective.
背景
总的来说，在甲型流感 2009（H1N1）大流行期间，密歇根州有 559 所学校关闭，作为非药物干预措施。
方法
通过将一个地区内关闭的学校比例与州流感样疾病（ILI）监测数据相联系，我们衡量了其对社区 ILI 水平的影响。本分析以每个学区 ILI 的高峰周为中心，使用负二项模型比较了三种学校关闭水平：从 ILI 高峰前的三周到 ILI 高峰后的四周，关闭 0%、1%-50%和 51%-100%的学校。
结果
我们发现学校关闭是被动的，在整个研究期间，ILI 率没有统计学上的显著差异。与关闭 0%的水平相比，关闭 51%-100%的学校的 ILI 发生率比值升高，而关闭 1%-50%的学校的 ILI 发生率比值降低。
结论
这些发现表明，地区层面的被动学校关闭措施无效。
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