中年及老年期心肺适能与老年期脑容量变化：巴尔的摩老年纵向研究结果
Midlife and Late-Life Cardiorespiratory Fitness and Brain Volume Changes in Late Adulthood: Results From the Baltimore Longitudinal Study of Aging.
作者信息
Tian Qu, Studenski Stephanie A, Resnick Susan M, Davatzikos Christos, Ferrucci Luigi
机构信息
Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland.
Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, Maryland.
出版信息
J Gerontol A Biol Sci Med Sci. 2016 Jan;71(1):124-30. doi: 10.1093/gerona/glv041. Epub 2015 Apr 19.
BACKGROUND
Higher cardiorespiratory fitness (CRF) is cross-sectionally associated with more conserved brain volume in older age, but longitudinal studies are rare. This study examined whether higher midlife CRF was prospectively associated with slower atrophy, which in turn was associated with higher late-life CRF.
METHODS
Brain volume by magnetic resonance imaging was determined annually from 1994 to 2003 in 146 participants (M baseline age = 69.6 years). Peak oxygen uptake on a treadmill yielded estimated midlife CRF in 138 and late-life CRF in 73 participants.
RESULTS
Higher midlife CRF was associated with greater middle temporal gyrus, perirhinal cortex, and temporal and parietal white matter, but was not associated with atrophy progression. Slower atrophy in middle frontal and angular gyri was associated with higher late-life CRF, independent of CRF at baseline magnetic resonance imaging.
CONCLUSIONS
Higher midlife CRF may play a role in preserving middle and medial temporal volumes in late adulthood. Slower atrophy in middle frontal and angular gyri may predict late-life CRF.
背景
较高的心肺适能（CRF）在横断面研究中与老年人脑容量的更多保留相关，但纵向研究较少。本研究调查了中年时较高的CRF是否与较慢的脑萎缩相关，而较慢的脑萎缩又与晚年较高的CRF相关。
方法
1994年至2003年期间，对146名参与者（基线年龄中位数=69.6岁）每年进行磁共振成像测量脑容量。通过跑步机上的峰值摄氧量得出138名参与者的中年CRF估计值和73名参与者的晚年CRF估计值。
结果
中年时较高的CRF与更大的颞中回、嗅周皮质以及颞叶和顶叶白质相关，但与萎缩进展无关。额中回和角回较慢的萎缩与晚年较高的CRF相关，且独立于基线磁共振成像时的CRF。
结论
中年时较高的CRF可能在成年晚期保留颞叶中部和内侧脑容量方面发挥作用。额中回和角回较慢的萎缩可能预测晚年的CRF。
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