Hontz Robert D, Guevara Carolina, Halsey Eric S, Silvas Jesus, Santiago Felix W, Widen Steven G, Wood Thomas G, Casanova Wilma, Vasilakis Nikos, Watts Douglas M, Kochel Tadeusz J, Ebihara Hideki, Aguilar Patricia V
Emerg Infect Dis. 2015 May;21(5):781-8. doi: 10.3201/eid2105.141368.
Our genetic analyses of uncharacterized bunyaviruses isolated in Peru identified a possible reassortant virus containing small and large gene segment sequences closely related to the Caraparu virus and a medium gene segment sequence potentially derived from an unidentified group C orthobunyavirus. Neutralization tests confirmed serologic distinction among the newly identified virus and the prototype and Caraparu strains. This virus, named Itaya, was isolated in 1999 and 2006 from febrile patients in the cities of Iquitos and Yurimaguas in Peru. The geographic distance between the 2 cases suggests that the Itaya virus could be widely distributed throughout the Amazon basin in northeastern Peru. Identification of a new Orthobunyavirus species that causes febrile disease in humans reinforces the need to expand viral disease surveillance in tropical regions of South America.
我们对在秘鲁分离出的未鉴定布尼亚病毒进行的基因分析，确定了一种可能的重配病毒，其小基因片段和大基因片段序列与卡拉帕鲁病毒密切相关，而中基因片段序列可能源自一种未鉴定的C组正布尼亚病毒。中和试验证实了新鉴定病毒与原型病毒及卡拉帕鲁毒株之间的血清学差异。这种名为伊塔亚的病毒于1999年和2006年从秘鲁伊基托斯和尤里马瓜斯市的发热患者中分离出来。这两例病例之间的地理距离表明，伊塔亚病毒可能广泛分布于秘鲁东北部的整个亚马逊盆地。鉴定出一种可导致人类发热疾病的新型正布尼亚病毒物种，强化了在南美洲热带地区扩大病毒性疾病监测的必要性。
