U.S. Naval Medical Research Unit Six, Lima, Peru.
PLoS Negl Trop Dis. 2011 Sep;5(9):e1315. doi: 10.1371/journal.pntd.0001315. Epub 2011 Sep 20.
Oropouche (ORO) virus, a member of the Simbu serogroup, is one of the few human pathogens in the Orthobunyavirus genus in the family Bunyaviridae. Genetic analyses of ORO-like strains from Iquitos, Peru, identified a novel reassortant containing the S and L segments of ORO virus and the M segment of a novel Simbu serogroup virus. This new pathogen, which we named Iquitos (IQT) virus, was first isolated during 1999 from a febrile patient in Iquitos, an Amazonian city in Peru. Subsequently, the virus was identified as the cause of outbreaks of "Oropouche fever" during 2005 and 2006 in Iquitos. In addition to the identification of 17 isolates of IQT virus between 1999 and 2006, surveys for neutralizing antibody among Iquitos residents revealed prevalence rates of 14.9% for ORO virus and 15.4% for IQT virus. Limited studies indicate that prior infection with ORO virus does not seem to protect against disease caused with the IQT virus infection. Identification of a new Orthobunyavirus human pathogen in the Amazon region of Peru highlights the need for strengthening surveillance activities and laboratory capabilities, and investigating the emergence of new pathogens in tropical regions of South America.
奥罗普切（ORO）病毒是辛布血清群中的一种，属于布尼亚病毒科正布尼亚病毒属的少数几种人类病原体之一。对来自秘鲁伊基托斯的类似 ORO 病毒株的遗传分析鉴定出一种新型重组病毒，该病毒包含 ORO 病毒的 S 和 L 片段以及新型辛布血清群病毒的 M 片段。这种新病原体最初于 1999 年从秘鲁亚马逊城市伊基托斯的一位发热患者中分离出来，我们将其命名为伊基托斯（IQT）病毒。随后，该病毒被确定为 2005 年和 2006 年伊基托斯爆发“奥罗普切热”的原因。除了在 1999 年至 2006 年间鉴定出 17 株 IQT 病毒外，对伊基托斯居民的中和抗体进行的调查显示，ORO 病毒的流行率为 14.9%，IQT 病毒的流行率为 15.4%。有限的研究表明，先前感染 ORO 病毒似乎并不能预防由 IQT 病毒感染引起的疾病。在秘鲁亚马逊地区发现一种新的正布尼亚病毒人类病原体，突显了加强监测活动和实验室能力的必要性，并需要调查南美洲热带地区新病原体的出现。
