4-羟基壬烯醛诱导一种类似于热休克因子的DNA结合蛋白。
4-Hydroxynonenal induces a DNA-binding protein similar to the heat-shock factor.
作者信息
Cajone F, Salina M, Benelli-Zazzera A
机构信息
Istituto di Patologia Generale dell'Universita degli Studi di Milano, Italy.
出版信息
Biochem J. 1989 Sep 15;262(3):977-9. doi: 10.1042/bj2620977.
Abstract
By using a gel mobility assay, we have shown that treatment of HeLa cells with 4-hydroxynonenal, a major product of the peroxidation of membrane lipids and an inducer of heat-shock proteins, has the same effect as heat shock in causing the appearance of a protein which binds to the sequence of DNA specific for the induction of heat-shock genes. Lipoperoxidation and heat exposure seem to share a common mechanism of specific gene activation.
摘要
通过凝胶迁移实验，我们发现，用4-羟基壬烯醛（一种膜脂过氧化的主要产物和热休克蛋白的诱导剂）处理HeLa细胞，在促使一种与热休克基因诱导特异性DNA序列结合的蛋白质出现方面，与热休克具有相同的效果。脂质过氧化和热暴露似乎有着共同的特异性基因激活机制。
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