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4-羟基壬烯醛诱导一种类似于热休克因子的DNA结合蛋白。

4-Hydroxynonenal induces a DNA-binding protein similar to the heat-shock factor.

作者信息

Cajone F, Salina M, Benelli-Zazzera A

机构信息

Istituto di Patologia Generale dell'Universita degli Studi di Milano, Italy.

出版信息

Biochem J. 1989 Sep 15;262(3):977-9. doi: 10.1042/bj2620977.

DOI:10.1042/bj2620977
PMID:2590181
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1133369/
Abstract

By using a gel mobility assay, we have shown that treatment of HeLa cells with 4-hydroxynonenal, a major product of the peroxidation of membrane lipids and an inducer of heat-shock proteins, has the same effect as heat shock in causing the appearance of a protein which binds to the sequence of DNA specific for the induction of heat-shock genes. Lipoperoxidation and heat exposure seem to share a common mechanism of specific gene activation.

摘要

通过凝胶迁移实验，我们发现，用4-羟基壬烯醛（一种膜脂过氧化的主要产物和热休克蛋白的诱导剂）处理HeLa细胞，在促使一种与热休克基因诱导特异性DNA序列结合的蛋白质出现方面，与热休克具有相同的效果。脂质过氧化和热暴露似乎有着共同的特异性基因激活机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8e4/1133369/8a11ec724fbd/biochemj00199-0279-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8e4/1133369/97491c99b0ba/biochemj00199-0279-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8e4/1133369/8a11ec724fbd/biochemj00199-0279-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8e4/1133369/97491c99b0ba/biochemj00199-0279-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8e4/1133369/8a11ec724fbd/biochemj00199-0279-b.jpg

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Biochem J. 1989 Sep 15;262(3):977-9. doi: 10.1042/bj2620977.
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In vitro activation of heat shock transcription factor by 4-hydroxynonenal.4-羟基壬烯醛对热休克转录因子的体外激活作用。
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本文引用的文献

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Transition series metals and sulfhydryl reagents induce the synthesis of four proteins in eukaryotic cells.过渡系列金属和巯基试剂可诱导真核细胞中四种蛋白质的合成。
Biochim Biophys Acta. 1980;606(1):170-80. doi: 10.1016/0005-2787(80)90108-2.
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Induction of glucose-regulated proteins during anaerobic exposure and of heat-shock proteins after reoxygenation.无氧暴露期间葡萄糖调节蛋白的诱导以及复氧后热休克蛋白的诱导。
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AppppA and related adenylylated nucleotides are synthesized as a consequence of oxidation stress.
从不完整训练数据中发现功能位点：以核酸结合蛋白为例的研究
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Small molecule activators of the heat shock response: chemical properties, molecular targets, and therapeutic promise.热休克反应小分子激活剂：化学性质、分子靶标和治疗前景。
Chem Res Toxicol. 2012 Oct 15;25(10):2036-53. doi: 10.1021/tx300264x. Epub 2012 Jul 31.
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Boosting the prediction and understanding of DNA-binding domains from sequence.从序列中提高 DNA 结合域的预测和理解能力。
Nucleic Acids Res. 2010 Jun;38(10):3149-58. doi: 10.1093/nar/gkq061. Epub 2010 Feb 15.
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Learning to translate sequence and structure to function: identifying DNA binding and membrane binding proteins.学习将序列和结构转化为功能：识别DNA结合蛋白和膜结合蛋白。
Ann Biomed Eng. 2007 Jun;35(6):1043-52. doi: 10.1007/s10439-007-9312-z. Epub 2007 Apr 13.
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Stathmin is involved in S100A4-mediated regulation of cell cycle progression.微管相关蛋白Stathmin参与S100A4介导的细胞周期进程调控。
Clin Exp Metastasis. 1999;17(10):865-71. doi: 10.1023/a:1006778804532.
AppppA及相关的腺苷酸化核苷酸是氧化应激的产物。 （注：原文中AppppA多了几个p，推测可能有误，正常应该是pppA之类的，这里按照正确理解翻译，但严格来说原文有误。）
Cell. 1984 May;37(1):225-32. doi: 10.1016/0092-8674(84)90318-0.
4
AppppA, heat-shock stress, and cell oxidation.载脂蛋白A、热休克应激与细胞氧化。 （你原文中多了几个p，推测可能有误，我按照合理内容翻译了，若不是这个意思可告知我）
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5
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Purification and properties of Drosophila heat shock activator protein.果蝇热休克激活蛋白的纯化及特性
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Induction of sequence-specific binding of Drosophila heat shock activator protein without protein synthesis.果蝇热休克激活蛋白序列特异性结合的诱导，无需蛋白质合成。
Nature. 1987;327(6124):727-30. doi: 10.1038/327727a0.
8
Heat-inducible human factor that binds to a human hsp70 promoter.与人类热休克蛋白70（hsp70）启动子结合的热诱导人类因子。
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9
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Chem Biol Interact. 1988;65(3):235-46. doi: 10.1016/0009-2797(88)90109-3.
10
Purification and characterization of a heat-shock element binding protein from yeast.酵母热休克元件结合蛋白的纯化与鉴定
EMBO J. 1987 Oct;6(10):3035-41. doi: 10.1002/j.1460-2075.1987.tb02609.x.